SynthesisBMJ (Clinical research ed.)2004
Combined use of rapid D-dimer testing and estimation of clinical probability in the diagnosis of deep vein thrombosis: systematic review.
Synthesis in BMJ (Clinical research ed.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 6 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- Diagnosis of deep vein thrombosis of the lower extremity: a systematic review and meta-analysis of test accuracy.Blood advances · 2020Pooled it
- Exclusion of deep vein thrombosis using the Wells rule in clinically important subgroups: individual patient data meta-analysis.BMJ (Clinical research ed.) · 2014Pooled it
- Guideline
- Excluding venous thromboembolism using point of care D-dimer tests in outpatients: a diagnostic meta-analysis.BMJ (Clinical research ed.) · 2009Pooled it
- Role of D-dimer in the Development of Portal Vein Thrombosis in Liver Cirrhosis: A Meta-analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationPooled it
- Current diagnosis of venous thromboembolism in primary care: a clinical practice guideline from the American Academy of Family Physicians and the American College of Physicians.Annals of family medicineGuideline
- Safety of a strategy combining D-dimer testing and whole-leg ultrasonography to rule out deep vein thrombosis.Blood advances · 2020Trial
- Diagnostic Performance of Immature Platelet Fraction in Patients with Suspected Deep Vein Thrombosis.Healthcare (Basel, Switzerland) · 2026Article
- Different diagnostic strategies using D-dimer for peripherally inserted central catheter-related upper extremity deep vein thrombosis.Journal of vascular surgery. Venous and lymphatic disorders · 2023Article
- Case report: Application of nonsurgical method in saving transplant renal vein thrombosis caused by acute diarrhea.Frontiers in medicine · 2023Article
- Nomogram for Predicting Deep Venous Thrombosis in Lower Extremity Fractures.BioMed research international · 2021Article
- Order Indication Solicitation to Assess Clinical Laboratory Test Utilization: D-Dimer Order Patterns as an Illustrative Case.Journal of pathology informatics · 2019Article
- Admission prevalence of deep vein thrombosis in elderly Chinese patients with hip fracture and a new predictor based on risk factors for thrombosis screening.BMC musculoskeletal disorders · 2018Article
- Evaluating the Use of a Negative D-Dimer and Modified Low Wells Score in Excluding above Knee Deep Venous Thrombosis in an Outpatient Population, Assessing Need for Diagnostic Ultrasound.ISRN radiology · 2014Article
- Enhanced pre-operative thrombolytic status is associated with the incidence of deep venous thrombosis in patients undergoing total knee arthroplasty.Thrombosis journal · 2014Article
- Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis.Biochemia medica · 2013Article
- Pulmonary embolism: investigation of the clinically assessed intermediate risk subgroup.The British journal of radiology · 2012Article
- [Phlebothrombosis of the leg. Diagnostic algorithm and therapeutic implications].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2010Article
- Another nail in the coffin for role of D-dimer in diagnosis of postoperative deep vein thrombosis!Annals of the Royal College of Surgeons of England · 2009Article
- Is it DVT? Wells score and D-dimer may avert costly workup.The Journal of family practice · 2007Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo summarise the evidence supporting the use of rapid d-dimer testing combined with estimation of clinical probability to exclude the diagnosis of deep venous thrombosis among outpatients. DATA SOURCES: Medline (June 1993 to December 2003), the Database of Abstracts and Reviews (DARE), and reference lists of studies in English. SELECTION OF STUDIES: We selected 12 studies from among 84 reviewed. The selected studies included more than 5000 patients and used a rapid D-dimer assay and explicit criteria to classify cases as having low, intermediate, or high clinical probability of deep vein thrombosis of the lower extremity among consecutive outpatients. REVIEW
methodsDiagnosis required objective confirmation, and untreated patients had to have at least three months of follow up. The outcome was objectively documented venous thromboembolism. Two authors independently abstracted data by using a data collection form.
resultsWhen the less sensitive SimpliRED D-dimer assay was used the three month incidence of venous thromboembolism was 0.5% (95% confidence interval 0.07% to 1.1%) among patients with a low clinical probability of deep vein thrombosis and normal D-dimer concentrations. When a highly sensitive D-dimer assay was used, the three month incidence of venous thromboembolism was 0.4% (0.04% to 1.1%) among outpatients with low or moderate clinical probability of deep vein thrombosis and a normal D-dimer concentration.
conclusionsThe combination of low clinical probability for deep vein thrombosis and a normal result from the SimpliRED D-dimer test safely excludes a diagnosis of acute venous thrombosis A normal result from a highly sensitive D-dimer test effectively rules out deep vein thrombosis among patients classified as having either low or moderate clinical probability of deep vein thrombosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.