ArticleBritish journal of pharmacology2004
CRF2 receptors are highly expressed in the human cardiovascular system and their cognate ligands urocortins 2 and 3 are potent vasodilators.
Article in British journal of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 88 citations in OpenAlex.
- Vascular effects of urocortins 2 and 3 in healthy volunteers.Journal of the American Heart Association · 2013Trial
- A unifying theory of brain signaling and its possible role in acquired chronic disease.Frontiers in neuroscience · 2026Article
- Urocortin 2 promotes hypertrophy and enhances skeletal muscle function through cAMP and insulin/IGF-1 signaling pathways.Molecular metabolism · 2022Article
- Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats.Diabetologia · 2022Article
- Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity.Peptides · 2022Review
- Article
- Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal.JACC. Basic to translational science · 2018Article
- Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing.Endocrinology · 2016Article
- Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.British journal of clinical pharmacology · 2016Article
- Comparative effects of urocortins and stresscopin on cardiac myocyte contractility.Journal of molecular and cellular cardiology · 2015Article
- Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice.Human gene therapy · 2015Article
- Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177.American journal of physiology. Heart and circulatory physiology · 2014Article
- NFAT transcription factor regulation by urocortin II in cardiac myocytes and heart failure.American journal of physiology. Heart and circulatory physiology · 2014Article
- Intravenous adeno-associated virus serotype 8 encoding urocortin-2 provides sustained augmentation of left ventricular function in mice.Human gene therapy · 2013Article
- Comparative pharmacokinetics and pharmacodynamics of urocortins 1, 2 and 3 in healthy sheep.British journal of pharmacology · 2012Article
- Urocortin-induced cardiomyocytes hypertrophy is associated with regulation of the GSK-3β pathway.Heart and vessels · 2012Article
- Central urocortin 3 and type 2 corticotropin-releasing factor receptor in the regulation of energy homeostasis: critical involvement of the ventromedial hypothalamus.Frontiers in endocrinology · 2012Article
- Distribution of urocortins and corticotropin-releasing factor receptors in the cardiovascular system.International journal of endocrinology · 2012Article
- Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder.Journal of psychiatric research · 2011Article
- Microinjections of urocortin1 into the nucleus ambiguus of the rat elicit bradycardia.American journal of physiology. Heart and circulatory physiology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Systemic infusions of urocortin 1 produce a decrease in mean arterial pressure. This effect may be mediated by a direct action on novel corticotropin-releasing factor type 2 (CRF(2)) receptors predicted to be expressed in blood vessels and the heart. Our objectives were to determine the presence of CRF(2) receptors in the human cardiovascular system using the selective radioligand [(125)I]antisauvagine 30. We also investigated the potential functional roles of novel CRF(2) ligands in the regulation of vascular tone in human arteries in vitro. 2. Radioligand binding techniques were used to characterise the CRF(2) receptor. [(125)I]antisauvagine 30 bound specifically, saturably, reversibly and with high affinity to CRF(2) receptors in human left ventricle (K(D) 0.21+/-0.03 nm, B(MAX) 0.80+/-0.18 fmol mg(-1) protein), and no change in receptor density or affinity was observed in the dilated cardiomyopathy group. 3. Autoradiographical studies revealed highly localised binding of [(125)I]antisauvagine 30 to intramyocardial blood vessels. Binding sites were also detected in the myocardium and in the medial layer of internal mammary arteries. 4. In endothelium-denuded human internal mammary artery in vitro, all peptides tested produced a potent and sustained vasodilator response reversing endothelin-1-induced constrictions (10 nm) (urocortin 1: pD(2) 8.39+/-0.32, E(MAX) 46+/-7.7%; urocortin 2: pD(2) 8.27+/-0.17, E(MAX) 60+/-8.5%; urocortin 3: pD(2) 8.61+/-0.25, E(MAX) 61+/-7.2%; CRF: pD(2) 8.28+/-0.27, E(MAX): 40+/-10%). 5. We have demonstrated the presence of CRF(2) receptors in the human cardiovascular system and a direct, endothelium-independent vasodilator action of urocortins 2 and 3, which may counter-balance the centrally mediated pressor effects of CRF and urocortin 1.
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