ArticleJournal of theoretical biology2004
How cellular movement determines the collective force generated by the Dictyostelium discoideum slug.
Article in Journal of theoretical biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
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- Differential cell motion: A mathematical model of anterior posterior sorting.Biophysical journal · 2023Article
- Free and Interfacial Boundaries in Individual-Based Models of Multicellular Biological systems.Bulletin of mathematical biology · 2023Article
- Data-driven spatio-temporal modelling of glioblastoma.Royal Society open science · 2023Review
- Biophysical models of early mammalian embryogenesis.Stem cell reports · 2023Review
- Hybrid models of chemotaxis with application to leukocyte migration.Journal of mathematical biology · 2021Article
- Collective invasion of glioma cells through OCT1 signalling and interaction with reactive astrocytes after surgery.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- A Review of Cell-Based Computational Modeling in Cancer Biology.JCO clinical cancer informatics · 2019Review
- Article
- Role of extracellular matrix and microenvironment in regulation of tumor growth and LAR-mediated invasion in glioblastoma.PloS one · 2018Article
- A 3D self-organizing multicellular epidermis model of barrier formation and hydration with realistic cell morphology based on EPISIM.Scientific reports · 2017Article
- A continuous-time model of centrally coordinated motion with random switching.Journal of mathematical biology · 2017Article
- Progress and perspectives in signal transduction, actin dynamics, and movement at the cell and tissue level: lessons fromInterface focus · 2016Review
- Hybrid models of cell and tissue dynamics in tumor growth.Mathematical biosciences and engineering : MBE · 2015Review
- Strategies of eradicating glioma cells: a multi-scale mathematical model with MiR-451-AMPK-mTOR control.PloS one · 2015Article
- Article
- Wound healing revised: a novel reepithelialization mechanism revealed by in vitro and in silico models.The Journal of cell biology · 2013Article
- A hybrid model of tumor-stromal interactions in breast cancer.Bulletin of mathematical biology · 2013Article
- An agent-based model for elasto-plastic mechanical interactions between cells, basement membrane and extracellular matrix.Mathematical biosciences and engineering : MBE · 2013Article
- Regulation of cell proliferation and migration in glioblastoma: new therapeutic approach.Frontiers in oncology · 2013Article
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Authors and funding
2 authors.
Funding
Abstract
How the collective motion of cells in a biological tissue originates in the behavior of a collection of individuals, each of which responds to the chemical and mechanical signals it receives from neighbors, is still poorly understood. Here we study this question for a particular system, the slug stage of the cellular slime mold Dictyostelium discoideum (Dd). We investigate how cells in the interior of a migrating slug can effectively transmit stress to the substrate and thereby contribute to the overall motive force. Theoretical analysis suggests necessary conditions on the behavior of individual cells, and computational results shed light on experimental results concerning the total force exerted by a migrating slug. The model predicts that only cells in contact with the substrate contribute to the translational motion of the slug. Since the model is not based specifically on the mechanical properties of Dd cells, the results suggest that this behavior will be found in many developing systems.
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