ArticleVirology2004
Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope.
Article in Virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- HIV-1-Infected CD4Journal of immunology (Baltimore, Md. : 1950) · 2022Article
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- Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.The Journal of experimental medicine · 2018Article
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- Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection.Journal of virus eradication · 2017Article
- T-Regulatory Cells and Vaccination "Pay Attention and Do Not Neglect Them": Lessons from HIV and Cancer Vaccine Trials.Vaccines · 2016Review
- The intracellular plasma membrane-connected compartment in the assembly of HIV-1 in human macrophages.BMC biology · 2016Article
- NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.Cell host & microbe · 2016Article
- CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo.Retrovirology · 2016Article
- HIV-1 Env Glycoprotein Phenotype along with Immune Activation Determines CD4 T Cell Loss in HIV Patients.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms.Journal of virology · 2015Article
- High-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry Inhibitors.Assay and drug development technologies · 2015Article
- Human T-Cell Development and Thymic Egress: An Infectious Disease Perspective.Forum on immunopathological diseases and therapeutics · 2015Article
- HIV-1 infection induces interleukin-1β production via TLR8 protein-dependent and NLRP3 inflammasome mechanisms in human monocytes.The Journal of biological chemistry · 2014Article
- Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice.PLoS pathogens · 2014Article
- Genetic signatures of HIV-1 envelope-mediated bystander apoptosis.The Journal of biological chemistry · 2014Article
- Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors.Organic & biomolecular chemistry · 2013Article
- Organization and regulation of intracellular plasma membrane-connected HIV-1 assembly compartments in macrophages.BMC biology · 2013Article
- Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.PLoS pathogens · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Loss of T cell homeostasis usually precedes the onset of AIDS. We hypothesized that rapid progressors may be transmitted with HIV-1 that is particularly able to perturb T cell homeostasis. To this end, we have tested two transmitted, syncytium-inducing (SI) viral isolates from a rapid progressor in two thymus models. One of the isolates (R3A) exhibited markedly rapid kinetics of replication and thymocyte depletion. These phenotypes mapped to the envelope, as a recombinant NL4-3 virus encoding the R3A envelope had similar phenotypes, even in the absence of nef. Notably, the viruses with high pathogenic activity in the thymus (R3A and NL4-R3A) did not show enhanced replication or cytopathicity in PHA-stimulated PBMCs. Furthermore, NL4-R3A did not enhance replication of the coinfected NL4-3 virus in the thymus, suggesting an intrinsic advantage of the R3A envelope. The R3A envelope showed higher entry activity in infecting human T cells and in depleting CD4+ thymocytes when expressed in trans. These data suggest that SI viruses with unique envelope functions which can overcome barriers to transmission may hasten disease progression by perturbing T cell homeostasis.
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