ReviewBMC dermatology2004
UVA/UVA1 phototherapy and PUVA photochemotherapy in connective tissue diseases and related disorders: a research based review.
Review in BMC dermatology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Evidence- and consensus-based guideline on lichen sclerosus.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026Guideline
- Assessing the Health Implications of UV/LED Nail Lamp Radiation Exposure During Manicure and Pedicure Procedures: A Scoping Review.International journal of dermatology · 2025Article
- [Localized scleroderma].Dermatologie (Heidelberg, Germany) · 2024Review
- UVA-Triggered Drug Release and Photo-Protection of Skin.Frontiers in cell and developmental biology · 2021Review
- Ultraviolet A1 Phototherapy for Fibrosing Conditions.Frontiers in medicine · 2018Review
- Photochemically Controlled Drug Dosing from a Polymeric Scaffold.Pharmaceutical research · 2017Article
- Phototherapy in Scleroderma.Dermatology and therapy · 2016Review
- Facial asymmetry: a case report of localized linear scleroderma patient with muscular strain and spasm.Maxillofacial plastic and reconstructive surgery · 2015Article
- Drug-loaded, bivalent-bottle-brush polymers by graft-through ROMP.Macromolecules · 2010Article
- Screening for in vitro phototoxic activity of methanol extracts of Croton campestris A., Ocimum gratissimum L. & Cordia verbenaceae DC.The Indian journal of medical research · 2010Article
- Rippled skin, fasciitis, and joint contractures.Journal of the American Academy of Dermatology · 2008Article
- Effect of increased pigmentation on the antifibrotic response of human skin to UV-A1 phototherapy.Archives of dermatology · 2008Article
- [Therapy of systemic sclerosis].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2007Review
- Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma.Expert review of dermatology · 2007Article
- Skin signs of systemic disease in childhood.Advances in dermatology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBroad-band UVA, long-wave UVA1 and PUVA treatment have been described as an alternative/adjunct therapeutic option in a number of inflammatory and malignant skin diseases. Nevertheless, controlled studies investigating the efficacy of UVA irradiation in connective tissue diseases and related disorders are rare.
methodsSearching the PubMed database the current article systematically reviews established and innovative therapeutic approaches of broad-band UVA irradiation, UVA1 phototherapy and PUVA photochemotherapy in a variety of different connective tissue disorders.
resultsPotential pathways include immunomodulation of inflammation, induction of collagenases and initiation of apoptosis. Even though holding the risk of carcinogenesis, photoaging or UV-induced exacerbation, UVA phototherapy seems to exhibit a tolerable risk/benefit ratio at least in systemic sclerosis, localized scleroderma, extragenital lichen sclerosus et atrophicus, sclerodermoid graft-versus-host disease, lupus erythematosus and a number of sclerotic rarities.
conclusionsBased on the data retrieved from the literature, therapeutic UVA exposure seems to be effective in connective tissue diseases and related disorders. However, more controlled investigations are needed in order to establish a clear-cut catalogue of indications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.