ArticleInternational journal of experimental pathology2004
Production of Heymann nephritis by a chemically modified renal antigen.
Article in International journal of experimental pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- The Modified Vaccination Technique.Vaccines · 2018Article
- Antibody-initiated beneficial and harmful immune responses.Immunologic research · 2018Review
- Tolerance, loss of tolerance and regaining tolerance to self by immune-mediated events.Immunologic research · 2017Article
- Regaining tolerance to a self-antigen by the modified vaccination technique.Clinical reviews in allergy & immunology · 2013Review
- Preventative and therapeutic vaccination to combat an experimental autoimmune kidney disease.Biologics : targets & therapy · 2007Article
- Down-regulation of pathogenic autoantibody response in a slowly progressive Heymann nephritis kidney disease model.International journal of experimental pathology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An autoimmune kidney disease morphologically and functionally similar to Heymann nephritis (HN) was induced in mature male Sprague Dawley rats by repeated weekly IP injections of a chemically modified azo sonicated ultracentrifuged (u/c) rat kidney fraction 3 (rKF3) antigen in an aqueous medium. The experiment was terminated 15 weeks after the first injection of the chemically altered antigen. Serum samples collected and analysed by an indirect fluorescent antibody test on normal rat kidney sections during the course of the experiment showed a gradual rise in circulating pathogenic autoantibodies directed against the proximal tubular brush border regions. Proteinuria was present and significantly increased in the urine of two of eight rats. The arising immune-complex glomerulonephritis (ICGN) revealed typical HN kidney disease lesions in 70% of the rats in histological, direct fluorescent antibody and electron-microscopical examinations. Control rats injected similarly with the an unmodified version of the same antigen did not develop the HN-characteristic morphological and functional changes. To our knowledge, this is the first time that the autoimmune kidney disease designated as an active HN has been produced by the administration of a chemically altered renal antigen in an aqueous solution and not by the usual presentation of the nephritogenic renal antigen in an adjuvant.
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Registered trials
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