ArticleDevelopment genes and evolution2004
Expression of three zebrafish orthologs of human FMR1-related genes and their phylogenetic relationships.
Article in Development genes and evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome.Human molecular genetics · 2024Article
- Cyfip2 controls the acoustic startle threshold through FMRP, actin polymerization, and GABAbioRxiv : the preprint server for biology · 2024Article
- RNA-Binding Proteins in the Post-transcriptional Control of Skeletal Muscle Development, Regeneration and Disease.Frontiers in cell and developmental biology · 2021Review
- Review
- Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish.PLoS genetics · 2015Article
- Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.Human molecular genetics · 2015Article
- Modeling fragile X syndrome in the Fmr1 knockout mouse.Intractable & rare diseases research · 2014Review
- Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development.Psychopharmacology · 2014Review
- Increasing our understanding of human cognition through the study of Fragile X Syndrome.Developmental neurobiology · 2014Review
- Mechanism of repeat-associated microRNAs in fragile X syndrome.Neural plasticity · 2012Review
- Conservation of the RNA Transport Machineries and Their Coupling to Translation Control across Eukaryotes.Comparative and functional genomics · 2012Article
- A presynaptic role for FMRP during protein synthesis-dependent long-term plasticity in Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- nev (cyfip2) is required for retinal lamination and axon guidance in the zebrafish retinotectal system.Developmental biology · 2010Article
- Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.Human molecular genetics · 2009Article
- Expression of fragile X mental retardation protein within the vocal control system of developing and adult male zebra finches.Neuroscience · 2008Article
- First in vivo evidence of microRNA-induced fragile X mental retardation syndrome.Molecular psychiatry · 2006Article
- The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis.Molecular biology of the cell · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human fragile X mental retardation syndrome is caused by expansions of a CGG repeat in the FMR1 gene. FXR1 and FXR2 are autosomal paralogs of FMR1. The products of the three genes, FMRP, FXR1P, and FXR2P, respectively, belong to a family of RNA-binding proteins. While the FMR1-related gene family is well described in human, mouse and Drosophila, little is known about zebrafish (Danio rerio) orthologs of these genes. Here we collate the known FMR1-related gene sequences from zebrafish, examine their regions of structural conservation, and define their orthologies with the human genes. We demonstrate that zebrafish possess only three FMR1-related genes, fmr1, fxr1 and fxr2, and these are orthologous to the human FMR1, FXR1 and FXR2 genes respectively. We examine the spatiotemporal pattern of transcription of the zebrafish genes from 0 hours post fertilisation (hpf) until 24 hpf. Expression of fmr1, fxr1 and fxr2 is widespread throughout this time. However, relative to surrounding tissues, expression of fxr2 is raised in adaxial and somitic cells by 12 hpf while fxr1 expression is high in the anterior of the embryo, and is raised in adaxial cells by 12 hpf. Distinct patterns (and levels) of expression are seen for the different genes later in development. At 24 hpf, fxr1 and fxr2 transcripts show complex distribution patterns in somites. The expression of the FMR1-related gene family in zebrafish tissues is broadly consistent with expression in mouse and human, supporting the idea that zebrafish should be an excellent model organism in which to study the functions of the vertebrate FMR1-related gene family.
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