ReviewOncogene2004
Does the reservoir for self-renewal stem from the ends?
Review in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Transcriptional Activation of Transposable Element (TE)-Associated Genes Is Frequently Associated with Altered Promoter Methylation in Placenta and Melanoma.International journal of molecular sciences · 2026Article
- Epigenetic Deregulation of Transposable Elements Links Developmental Processes and Tumorigenesis.International journal of molecular sciences · 2026Review
- Cell Immortalization: In Vivo Molecular Bases and In Vitro Techniques for Obtention.Biotech (Basel (Switzerland)) · 2023Review
- Is Adipose Tissue the Fountain of Youth? The Impact of Adipose Stem Cell Aging on Metabolic Homeostasis, Longevity, and Cell-Based Therapies.Advances in experimental medicine and biology · 2021Review
- Extra-telomeric impact of telomeres: Emerging molecular connections in pluripotency or stemness.The Journal of biological chemistry · 2020Review
- Reawakening the Developmental Origins of Cancer Through Transposable Elements.Frontiers in oncology · 2020Article
- Experimental manipulation of telomere length: does it reveal a corner-stone role for telomerase in the natural variability of individual fitness?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation.The Journal of cell biology · 2016Article
- Are hematopoietic stem cells involved in hepatocarcinogenesis?Hepatobiliary surgery and nutrition · 2014Review
- G-quadruplexes as potential therapeutic targets for embryonal tumors.Molecules (Basel, Switzerland) · 2013Review
- Cancer stem cells: relevance to clinical transplantation.Current opinion in oncology · 2012Review
- Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers.BMC biotechnology · 2011Article
- Article
- Cancer stem cells-clinical relevance.Journal of molecular medicine (Berlin, Germany) · 2009Review
- A genome-wide screen for essential yeast genes that affect telomere length maintenance.Nucleic acids research · 2009Article
- Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer.Journal of cellular and molecular medicine · 2008Article
- Small intestinal stem cell markers.Journal of anatomy · 2008Review
- The longest telomeres: a general signature of adult stem cell compartments.Genes & development · 2008Article
- A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis.PloS one · 2008Article
- Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres.The Journal of cell biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Stem cell research is a burgeoning field with an alluring potential for therapeutic intervention, and thus begs a critical understanding of the long-term consequences of stem cell replacement. Operationally, a stem cell may be defined as a rarely dividing cell with the capacity for self-renewal throughout the lifetime of the organism, and an ability to reconstitute its appropriate lineages via proliferation and differentiation. In many differentiated normal and cancer cell types, the maintenance of telomeres plays a pivotal role in their continued division potential. Taken together with the presence of the enzymatic activity responsible for telomere addition, telomerase, in several progenitor cell lineages, it is presumed that telomere maintenance will be critical for the replenishment of stem cells or their successors. The purpose of this review is to discuss the role of telomere length maintenance in self-renewal, and the consequent challenges and potential pitfalls to the manipulation of normal and cancer-derived stem cells.
Indexed as
Identifiers
15378088What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.