ArticleOncogene2004
Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues iniScience · 2023Article
- Inter-Species Rescue of Mutant Phenotype-The Standard for Genetic Analysis of Human Genetic Disorders inInternational journal of molecular sciences · 2022Review
- COMPASS and SWI/SNF complexes in development and disease.Nature reviews. Genetics · 2021Review
- The Leukemic Fly: Promises and Challenges.Cells · 2020Review
- Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities.Wellcome open research · 2020Article
- Novel sub-cellular localizations and intra-molecular interactions may define new functions of Mixed Lineage Leukemia protein.Cell cycle (Georgetown, Tex.) · 2018Article
- Transcriptional regulation by trithorax-group proteins.Cold Spring Harbor perspectives in biology · 2014Review
- The ribonuclease Dis3 is an essential regulator of the developmental transcriptome.BMC genomics · 2012Article
- Trithorax group proteins: switching genes on and keeping them active.Nature reviews. Molecular cell biology · 2011Review
- Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions.Genes & development · 2007Article
- Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement.Leukemia · 2007Article
- Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.Genes & development · 2006Article
- A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy.Blood · 2006Article
- Molecular pathogenesis of MLL-associated leukemias.International journal of hematology · 2005Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Mixed Lineage Leukemia (MLL) gene is involved in lymphoblastic and myeloid leukemia through chromosome translocations leading to fusion of MLL to partner genes, or through internal MLL rearrangements. MLL is the mammalian counterpart of the Drosophila trithorax (trx) gene, involved in maintaining active gene expression states. We have used transgenic Drosophila to assess the molecular targets and cellular processes affected by MLL and two of its leukemic fusion proteins. We find that whereas expression of normal human MLL in flies does not result in phenotypic alterations, overexpressing the human MLL-AF9 and MLL-AF4 proteins causes larval to pupal lethality, which interestingly resembles the phenotypes displayed by certain Drosophila trx mutant alleles. MLL-AF9 and MLL-AF4 transgenic flies exhibit antagonistic alterations in cell cycle progression. Additionally, flies expressing MLL-AF9 display impairment in higher order chromatin integrity, evidenced in decondensation of mitotic figures. The effects of MLL fusion proteins in Drosophila suggest that alteration of chromatin structure by MLL fusion proteins may contribute to the lethal phenotype. Our results indicate that the mode(s) of action of MLL-AF9 in Drosophila varies from that of MLL-AF4. Taken together, the expression of MLL fusion proteins in Drosophila provides a new and powerful system to reveal and characterize biological activities associated with MLL fusion proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.