ArticleOncogene2004
Allelic imbalance of APAF-1 locus at 12q23 is related to progression of colorectal carcinoma.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Predictive utility of circulating methylated DNA in serum of melanoma patients receiving biochemotherapy.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2005Trial
- LNC473 Regulating APAF1 IRES-Dependent Translation via Competitive Sponging miR574 and miR15b: Implications in Colorectal Cancer.Molecular therapy. Nucleic acids · 2020Article
- Emerging technologies for studying DNA methylation for the molecular diagnosis of cancer.Expert review of molecular diagnostics · 2015Review
- Apoptosis, autophagy, necroptosis, and cancer metastasis.Molecular cancer · 2015Review
- DNA methylation of apoptosis genes in rectal cancer predicts patient survival and tumor recurrence.Apoptosis : an international journal on programmed cell death · 2014Article
- Evading apoptosis in cancer.Trends in cell biology · 2013Review
- Screening for differentially methylated genes among human colorectal cancer tissues and normal mucosa by microarray chip.Molecular biology reports · 2013Article
- Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese.PLoS genetics · 2013Article
- Evaluation of allele-specific somatic changes of genome-wide association study susceptibility alleles in human colorectal cancers.PloS one · 2012Article
- Epigenetic contributions to cancer metastasis.Clinical & experimental metastasis · 2009Article
- Rationales for expression and altered expression of apoptotic protease activating factor-1 gene in gastric cancer.World journal of gastroenterology · 2007Article
- Cancer despite immunosurveillance: immunoselection and immunosubversion.Nature reviews. Immunology · 2006Review
- Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer.Oncogene · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
APAF-1 gene, located at chromosome locus 12q23, is a key factor in the mitochondrial apoptotic pathway downstream of p53, and is a potential tumor suppressor gene. We hypothesized that APAF-1 gene dysfunction due to allelic imbalance (AI) contributes to the development and progression of colorectal carcinoma (CRC). AI at APAF-1 locus and microsatellite instability (MIN) in CRCs and adenomas were assessed by multiple microsatellite markers. The frequency of AI significantly increased with tumor progression; 0 of 33 (0%) adenomas, 14 of 49 (29%) primary CRCs, and 18 of 34 (53%) liver metastases had AI. A total of 12 metastases were matched with corresponding primary CRCs; in 11 of 12 (92%) pairs, the metastasis had same AI status as the corresponding primary tumor. APAF-1 mRNA transcription level was significantly decreased with AI in liver metastases (P=0.009). Promoter hypermethylation was found in three of 35 (9%) primary CRCs and one of 15 (7%) liver metastases by methylation-specific PCR but was not correlated with AI. MIN was observed in 11 of 49 (23%) primary CRCs and was a favorable prognostic factor. Our results suggest that APAF-1 gene haploinsufficiency caused by AI increases with tumor progression, and relates to hepatic metastasis.
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Registered trials
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