ArticleOncogene2004
Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 85 citations in OpenAlex.
- Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis.Nature communications · 2022Article
- The COL11A1/Akt/CREB signaling axis enables mitochondrial-mediated apoptotic evasion to promote chemoresistance in pancreatic cancer cells through modulating BAX/BCL-2 function.Journal of Cancer · 2021Article
- Autophagy activation contributes to glutathione transferase Mu 1-mediated chemoresistance in hepatocellular carcinoma.Oncology letters · 2018Article
- Calcium Contributes to the Cytotoxic Interaction Between Diclofenac and Cytokines.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition.Oncogene · 2015Review
- 1‑calcium phosphate‑uracil, a synthesized pyrimidine derivative agent, has anti‑proliferative, pro‑apoptotic and anti‑invasion effects on multiple tumor cell lines.Molecular medicine reports · 2014Article
- Differential expression of transcription factors and inflammation-, ROS-, and cell death-related genes in organotypic cultures in the modiolus, the organ of Corti and the stria vascularis of newborn rats.Cellular and molecular neurobiology · 2014Article
- CKMT1 regulates the mitochondrial permeability transition pore in a process that provides evidence for alternative forms of the complex.Journal of cell science · 2014Article
- Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition.Cell cycle (Georgetown, Tex.) · 2013Article
- Tamoxifen induces apoptosis of mouse microglia cell line BV-2 cells via both mitochondrial and death receptor pathways.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2012Article
- Identification of specific pluripotent stem cell death--inducing small molecules by chemical screening.Stem cell reviews and reports · 2012Article
- VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria.Cell death and differentiation · 2012Article
- Health and cellular impacts of air pollutants: from cytoprotection to cytotoxicity.Biochemistry research international · 2012Article
- Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.PloS one · 2012Article
- Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy.Journal of translational medicine · 2011Article
- Mitochondrial metabolism inhibitors for cancer therapy.Pharmaceutical research · 2011Review
- Adenine nucleotide translocase family: four isoforms for apoptosis modulation in cancer.Oncogene · 2011Review
- Glutathionylation of adenine nucleotide translocase induced by carbon monoxide prevents mitochondrial membrane permeabilization and apoptosis.The Journal of biological chemistry · 2010Article
- Apoptosis in leukemias: regulation and therapeutic targeting.Cancer treatment and research · 2010Review
- Biochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cells.The Biochemical journal · 2009Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mitochondrial permeability transition pore complex (PTPC) is involved in the control of the mitochondrial membrane permeabilization during apoptosis, necrosis and autophagy. Indeed, the adenine nucleotide translocator (ANT) and the voltage-dependent anion channel (VDAC), two major components of PTPC, are the targets of a variety of proapoptotic inducers. Using co-immunoprecipitation and proteomic analysis, we identified some of the interacting partners of ANT in several normal tissues and human cancer cell lines. During chemotherapy-induced apoptosis, some of these interactions were constant (e.g. ANT-VDAC), whereas others changed strongly concomitantly with the dissipation of the mitochondrial transmembrane potential and until nuclear degradation occurred (e.g. Bax, Bcl-2, subunits of the respiratory chain, a subunit of the phosphatase PP2A, phospholipase PLC beta 4 and IP3 receptor). In addition, a glutathione-S-transferase (GST) interacts with ANT in normal tissue, in colon carcinoma cells and in vitro. This interaction is lost during apoptosis induction, suggesting that GST behaves as an endogenous repressor of PTPC and ANT pore opening. Thus, ANT is connected to mitochondrial proteins as well as to proteins from other organelles such as the endoplasmic reticulum forming a dynamic polyprotein complex. Changes within this ANT interactome coordinate the lethal response of cells to apoptosis induction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.