ArticleThe British journal of ophthalmology2004
Serum paraoxonase activity is decreased in the active stage of Behçet's disease.
Article in The British journal of ophthalmology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Salivary Oxidative Stress Markers in Behcet's: A Comparative Study of Active and Inactive Diseases.Health science reports · 2025Article
- Oxidative stress in otosclerosis.Redox report : communications in free radical research · 2017Article
- Serum paraoxonase activity, total thiols levels, and oxidative status in patients with acute brucellosis.Wiener klinische Wochenschrift · 2015Article
- Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma.International journal of ophthalmology · 2015Article
- Serum paraoxonase and arylesterase activities in patients with chronic otitis media.Redox report : communications in free radical research · 2015Article
- PEP-1-PON1 protein regulates inflammatory response in raw 264.7 macrophages and ameliorates inflammation in a TPA-induced animal model.PloS one · 2014Article
- Serum paraoxonase, arylesterase activity, and oxidative status in patients with nasal polyp.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- Oxidative stress in chronic otitis media.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- Reduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stress.Redox report : communications in free radical research · 2012Article
- Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients.Clinics (Sao Paulo, Brazil) · 2010Article
- Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1.The Journal of clinical investigation · 2008Article
- Serum paraoxonase undergoes inhibition and proteolysis during experimental acute pancreatitis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2008Article
- Serum oxidative-antioxidative status in patients with ankylosing spondilitis.Rheumatology international · 2007Article
- Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet's disease.Indian journal of dermatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate paraoxonase1 (PON1) activities and malondialdehyde (MDA) levels, one of the end products of lipid peroxidation induced by reactive oxygen species in patients with Behçet's disease (BD) in the active stage.
methodsSerum MDA levels and PON1 levels were measured spectrophotometrically in 16 patients with BD in the active stage of the disease and in 15 healthy subjects who constituted the control group.
resultsIn the BD group, median (range) serum PON1 and MDA levels were 149.64 U/l (88.02-281.68) and 1.21 nmol/ml (0.90-3.42), respectively. In the control group, median (range) serum PON1 and MDA levels were 206.86 U/l (114.43-422.52) and 0.72 nmol/ml (0.50-1.12), respectively. There was a statistically significant decrease in serum PON1 levels (p = 0.02) and an increase in serum MDA levels (p<0.001) in patients with BD in the active stage when compared to controls.
conclusionEndothelial damage and increased polymorph nuclear leucocyte activity in the active stage of BD could result in a pro-oxidation environment which, in turn, results in decreased antioxidant PON activity and increased lipid peroxidation as evidenced by increased MDA levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.