ArticleBiophysical journal2004
Molecular view of hexagonal phase formation in phospholipid membranes.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 210 citations in OpenAlex.
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- Lipidomic profiling of influenza A virus production in MDCK cells towards targeted clone selection.Scientific reports · 2026Article
- Tumor mRNA-lipid nanoparticles via chimeric nanobody-lipid co-assembly.Theranostics · 2026Article
- Development of Transferable Coarse-Grained Lipid Models with Optimized Structural and Elastic Membrane Properties.Journal of chemical theory and computation · 2025Article
- Peroxisome Dysfunction and Steatotic Liver Disease.International journal of molecular sciences · 2025Review
- Molecular level insight into non-bilayer structure formation in thylakoid membranes: a molecular dynamics study.Photosynthesis research · 2025Article
- Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection.Nature communications · 2024Article
- How Did Thylakoids Emerge in Cyanobacteria, and How Were the Primary Chloroplast and Chromatophore Acquired?Methods in molecular biology (Clifton, N.J.) · 2024Article
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- Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms ineLife · 2023Article
- Cr(vi) permanently binds to the lipid bilayer in an inverted hexagonal phase throughout the reduction process.RSC advances · 2023Article
- Bacterial lipids drive compartmentalization on the nanoscale.Nanoscale · 2023Article
- Ether Lipid-Mediated Antioxidant Defense in Alzheimer's Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Modulating membrane fusion through the design of fusogenic DNA circuits and bilayer composition.Soft matter · 2022Article
- Chloroplast membrane lipid remodeling protects against dehydration by limiting membrane fusion and distortion.Plant physiology · 2022Article
- Effect of Ursolic and Oleanolic Acids on Lipid Membranes: Studies on MRSA and Models of Membranes.Antibiotics (Basel, Switzerland) · 2021Article
- NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Important biological processes, such as vesicle fusion or budding, require the cell matrix to undergo a transition from a lamellar to a nonlamellar state. Although equilibrium properties of membranes are amenable to detailed theoretical studies, collective rearrangements involved in phase transitions have thus far only been modeled on a qualitative level. Here, for the first time, the complete transition pathway from a multilamellar to an inverted hexagonal phase is elucidated at near-atomic detail using a recently developed coarse-grained molecular dynamics simulation model. Insight is provided into experimentally inaccessible data such as the molecular structure of the intermediates and the kinetics involved. Starting from multilamellar configurations, the spontaneous formation of stalks between the bilayers is observed on a nanosecond timescale at elevated temperatures or reduced hydration levels. The stalks subsequently elongate in a cooperative manner leading to the formation of an inverted hexagonal phase. The rate of stalk elongation is approximately 0.1 nm ns(-1). Within a narrow hydration/temperature/composition range the stalks appear stable and rearrange into the rhombohedral phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.