ArticleRespiratory research2004
Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2.
Article in Respiratory research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Inactivation of the gene encoding procalcitonin prevents antibody-mediated arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- Correlation analysis of monocyte chemoattractant protein-1 and clinical characteristics and cognitive impairment in type 2 diabetes mellitus comorbid major depressive disorder.Frontiers in aging neuroscience · 2023Article
- MicroRNA-142-3p inhibits IFN-γ production via targeting of RICTOR inAnnals of translational medicine · 2019Article
- Type 2 immunity in tissue repair and fibrosis.Nature reviews. Immunology · 2018Review
- Type 2 Immune Mechanisms in Carbon Nanotube-Induced Lung Fibrosis.Frontiers in immunology · 2018Review
- Overexpression of biologically safe Rorippa indica defensin enhances aphid tolerance in Brassica juncea.Planta · 2017Article
- Serum opsonin ficolin-A enhances host-fungal interactions and modulates cytokine expression from human monocyte-derived macrophages and neutrophils following Aspergillus fumigatus challenge.Medical microbiology and immunology · 2016Article
- Role of C-C motif ligand 2 and C-C motif receptor 2 in murine pulmonary graft-versus-host disease after lipopolysaccharide inhalations.American journal of respiratory cell and molecular biology · 2014Article
- Nickel nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor, TBX21 (T-bet).Particle and fibre toxicology · 2014Article
- Neonatal hyperoxia alters the host response to influenza A virus infection in adult mice through multiple pathways.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Role of ficolin-A and lectin complement pathway in the innate defense against pathogenic Aspergillus species.Infection and immunity · 2013Article
- Article
- A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Article
- An inhalation model of airway allergic response to inhalation of environmental Aspergillus fumigatus conidia in sensitized BALB/c mice.Medical mycology · 2010Article
- DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Effects of intratracheal administration of nuclear factor-kappaB decoy oligodeoxynucleotides on long-term cigarette smoke-induced lung inflammation and pathology in mice.Respiratory research · 2009Article
- A polymorphism in the CCL2 chemokine gene is associated with asthma risk: a case-control and a family study in Tunisia.Genes and immunity · 2008Article
- The role of chemokines in virus-associated asthma exacerbations.Current allergy and asthma reports · 2008Review
- Animal models: an important tool in mycology.Medical mycology · 2007Review
- A role for MCP-1/CCR2 in interstitial lung disease in children.Respiratory research · 2005Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is characterized by type 2 T-helper cell (Th2) inflammation, goblet cell hyperplasia, airway hyperreactivity, and airway fibrosis. Monocyte chemoattractant protein-1 (MCP-1 or CCL2) and its receptor, CCR2, have been shown to play important roles in the development of Th2 inflammation. CCR2-deficient mice have been found to have altered inflammatory and physiologic responses in some models of experimental allergic asthma, but the role of CCR2 in contributing to inflammation and airway hyperreactivity appears to vary considerably between models. Furthermore, MCP-1-deficient mice have not previously been studied in models of experimental allergic asthma.
methodsTo test whether MCP-1 and CCR2 are each required for the development of experimental allergic asthma, we applied an Aspergillus antigen-induced model of Th2 cytokine-driven allergic asthma associated with airway fibrosis to mice deficient in either MCP-1 or CCR2. Previous studies with live Aspergillus conidia instilled into the lung revealed that MCP-1 and CCR2 play a role in anti-fungal responses; in contrast, we used a non-viable Aspergillus antigen preparation known to induce a robust eosinophilic inflammatory response.
resultsWe found that wild-type C57BL/6 mice developed eosinophilic airway inflammation, goblet cell hyperplasia, airway hyperreactivity, elevations in serum IgE, and airway fibrosis in response to airway challenge with Aspergillus antigen. Surprisingly, mice deficient in either MCP-1 or CCR2 had responses to Aspergillus antigen similar to those seen in wild-type mice, including production of Th2 cytokines.
conclusionWe conclude that robust Th2-mediated lung pathology can occur even in the complete absence of MCP-1 or CCR2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.