ReviewCNS drugs2004
Tocopherol (vitamin E) in Alzheimer's disease and other neurodegenerative disorders.
Review in CNS drugs, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Efficacy of antioxidants as a therapy for Alzheimer's disease: a meta-analysis.Frontiers in nutrition · 2026Pooled it
- Vitamin E serum levels and controlled supplementation and risk of amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2013Trial
- Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer's disease: a 1-year, open-label pilot study with an 16-month caregiver extension.American journal of Alzheimer's disease and other dementiasTrial
- The role of α-tocopherol in the prevention and treatment of Alzheimer's disease.Molecular and cellular biochemistry · 2025Review
- A Comparative Study on the Mycelium and Fruiting Body ofCurrent issues in molecular biology · 2025Article
- Identification of Six Cerebrospinal Fluid Metabolites Causally Associated with Anorexia Nervosa Risk: A Mendelian Randomization Analysis.International journal of molecular sciences · 2025Article
- Variable Bioproduction with Euglena gracilis: A Function of Light Flux or Carbon Source, Supplements, and Time.Advances in biochemical engineering/biotechnology · 2025Review
- Genotypic variation of tocopherol content in a representative genetic population and genome-wide association study on tocopherol in rapeseed (Molecular breeding : new strategies in plant improvement · 2023Article
- Natural Bioactive Molecules as Neuromedicines for the Treatment/Prevention of Neurodegenerative Diseases.ACS omega · 2023Review
- Current Naturopathy to Combat Alzheimer's Disease.Current neuropharmacology · 2023Review
- Chemosensitization Effect of Seabuckthorn (Foods (Basel, Switzerland) · 2022Article
- Analyzing the Therapeutic Mechanism of Mongolian MedicineEvidence-based complementary and alternative medicine : eCAM · 2022Article
- High-throughput determination of vitamin E in extra virgin olive oil by paper spray tandem mass spectrometry.Analytical and bioanalytical chemistry · 2019Article
- FromFrontiers in plant science · 2018Review
- Bioactive Properties of Tabebuia impetiginosa-Based Phytopreparations and Phytoformulations: A Comparison between Extracts and Dietary Supplements.Molecules (Basel, Switzerland) · 2015Article
- Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of aberrant cell cycle diseases: an update.TheScientificWorldJournal · 2012Review
- Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of central nervous system diseases.Neurobiology of disease · 2010Review
- Protective effect of some vitamins against the toxic action of ethanol on liver regeneration induced by partial hepatectomy in rats.World journal of gastroenterology · 2008Article
- Prevention of Alzheimer disease. Encouraging evidence.Canadian family physician Medecin de famille canadien · 2006Review
- Alpha-tocopherol: roles in prevention and therapy of human disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this article, we review the evidence that tocopherol (vitamin E) may have a role to play in the prevention and treatment of Alzheimer's disease and other neurological diseases. The theoretical rationale for the effectiveness of tocopherol as treatment and/or prevention of Alzheimer's disease is based on its antioxidant properties. Results from animal and in vitro studies provide evidence to support use of tocopherol for prevention and treatment of degenerative neurological diseases. Furthermore, several, but not all, epidemiological, cross-sectional, prospective studies indicate that tocopherol may have protective effects in Alzheimer's disease, although dietary and supplemental forms of the vitamin may differ in their efficacy. Mixed results have been obtained from clinical trials. Evidence of the use of tocopherol as a protective measure or as therapy in neurological diseases other than Alzheimer's disease is less compelling. To date, there are no clear-cut answers as to whether tocopherol is worth prescribing, but current clinical practice favours its use in the treatment of Alzheimer's disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.