ArticleImmunology1992
Inactivation of platelet-activating factor by a putative acetylhydrolase from the gastrointestinal nematode parasite Nippostrongylus brasiliensis.
Article in Immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- The Immune Response to Nematode Infection.International journal of molecular sciences · 2023Review
- Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis.Parasite immunology · 2022Review
- Host parasite communications-Messages from helminths for the immune system: Parasite communication and cell-cell interactions.Molecular and biochemical parasitology · 2016Review
- Looking beyond the induction of Th2 responses to explain immunomodulation by helminths.Parasite immunology · 2015Review
- Modulation of anaphylaxis by helminth-derived products in animal models.Current allergy and asthma reports · 2007Review
- Review
- Platelet-activating factor receptor deficiency delays elimination of adult worms but reduces fecundity in Strongyloides venezuelensis-infected mice.Infection and immunity · 2004Article
- Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites.Genome biology · 2004Article
- Modulation of a heterologous immune response by the products of Ascaris suum.Infection and immunity · 2002Article
- Characterization of a platelet-activating factor acetylhydrolase secreted by the nematode parasite Nippostrongylus brasiliensis.The Biochemical journal · 1996Article
- The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF.The Journal of cell biology · 1994Article
- Article
- Article
- Review
- Intravascular filarial parasites inhibit platelet aggregation. Role of parasite-derived prostanoids.The Journal of clinical investigation · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The adult stage of Nippostrongylus brasiliensis, a strongyloid parasite of the gastrointestinal tract of rats, released a product during in vitro culture which functionally inhibited platelet-activating factor (PAF), measured by its ability to mediate platelet aggregation. The extent of inhibition was proportional to the concentration of excretory/secretory (ES) products and the duration of preincubation with PAF prior to the assay of biological activity. The inhibitory activity was heat labile and was specific for PAF, as incubation of ES products with thrombin showed no diminution of platelet aggregation. Experiments using radiolabelled preparations of PAF demonstrated that the acetyl group esterified at the sn-2 position of the glycerol backbone was liberated on incubation with ES products, indicative of an acetylhydrolase activity. This activity was susceptible to inhibition by DFP, partial inhibition by eserine, but was resistant to PMSF and TPCK at concentrations which inhibit serine proteases.
Indexed as
Identifiers
1537601PMC1384800W2409460963What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.