ArticleJournal of bacteriology2004
Two chimeric chromosomes of Streptomyces coelicolor A3(2) generated by single crossover of the wild-type chromosome and linear plasmid scp1.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Evidence supporting the first secondary chromosome in Actinobacteria as a hallmark of theMicrobial genomics · 2026Article
- Bilateral symmetry of linear streptomycete chromosomes.Microbial genomics · 2021Article
- Telomeric and sub-telomeric regions undergo rapid turnover within a Streptomyces population.Scientific reports · 2020Article
- Genome plasticity is governed by double strand break DNA repair in Streptomyces.Scientific reports · 2018Article
- Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers.Journal of natural products · 2018Article
- Horizontal gene transfer and gene conversion drive evolution of modular polyketide synthases.Journal of industrial microbiology & biotechnology · 2012Article
- A novel docking domain interface model predicting recombination between homoeologous modular biosynthetic gene clusters.Journal of industrial microbiology & biotechnology · 2011Article
- The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.Genome biology and evolution · 2010Article
- Genomic basis for natural product biosynthetic diversity in the actinomycetes.Natural product reports · 2009Review
- Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptomyces coelicolor A3(2) strain 2106 carries a 1.85-Mb linear plasmid, SCP1'-cysD, in addition to a 7.2-Mb linear chromosome. Macrorestriction analysis indicated that both linear DNAs are hybrids of the wild-type chromosome and the linear plasmid SCP1 on each side. Nucleotide sequencing of the fusion junctions revealed no homology between the recombination regions. SCP1'-cysD contains an SCP1 telomere and a chromosomal telomere at each end and therefore does not have terminal inverted repeats. In addition, SCP1'-cysD could not be eliminated from strain 2106 by various mutagenic treatments. Thus, we concluded that both the 7.2-Mb chromosome and SCP1'-cysD are chimeric chromosomes generated by a single crossover of the wild-type chromosome and SCP1. This may be regarded as a model of chromosomal duplication in genome evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.