ArticleClinical and experimental immunology2004
High prevalence of autoantibodies among Danish centenarians.
Article in Clinical and experimental immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
- The long-lived immune system of centenarians.Nature reviews. Immunology · 2026Review
- Autoantibody Positivity in Bronchiectasis Without Interstitial Lung Diseases: Risk Factors and Impact on Clinical Features.Journal of clinical medicine · 2026Article
- Zinc deficiency as possible link between immunosenescence and age-related diseases.Immunity & ageing : I & A · 2025Review
- Autoantibodies targeting angiotensin-converting enzyme 2 are prevalent and not induced by SARS-CoV-2 infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Autoimmunity in centenarians. A paradox.Journal of translational autoimmunity · 2024Review
- Immune aging - A mechanism in autoimmune disease.Seminars in immunology · 2023Review
- Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4Immunity & ageing : I & A · 2023Article
- Activation of a Latent Epitope Causing Differential Binding of Antineutrophil Cytoplasmic Antibodies to Proteinase 3.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- Altered Antibody Response to Epstein-Barr Virus in Patients With Rheumatoid Arthritis and Healthy Subjects Predisposed to the Disease. A Twin Study.Frontiers in immunology · 2021Article
- The effect of ageing on the resolution of inflammation.Ageing research reviews · 2020Review
- Subclinical Hypothyroidism: is it Really Subclinical with Aging?Aging and disease · 2019Article
- Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders-findings of a multicenter population-based study.Arthritis research & therapy · 2017Article
- Demographic associations for autoantibodies in disease-free individuals of a European population.Scientific reports · 2017Article
- The Impact of Immunosenescence on Pulmonary Disease.Mediators of inflammation · 2015Review
- The immunopathology of ANCA-associated vasculitis.Seminars in immunopathology · 2014Review
- Age-related autoimmunity.BMC medicine · 2013Article
- Delayed development of pulmonary hemorrhage in a patient with positive circulating anti-neutrophil cytoplasmic antibody: a clinical dilemma.Case reports in nephrology and urology · 2013Article
- Circulating antinuclear antibodies in patients with pelvic masses are associated with malignancy and decreased survival.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the prevalence of organ and nonorgan specific autoantibodies in relation to disability and comorbidity in an unselected population of centenarians. A population-based survey of all persons living in Denmark who celebrated their 100th birthday during the period 1 April 1995 to 31 May 1996, a total of 276 persons, was undertaken. Participants underwent an interview, a physical examination and blood sampling. Organ specific autoantibodies (Tg-ab, TPO-ab, PCA-ab) and nonorgan specific autoantibodies (ANA, IgM RF, IgA RF, MPO-ab, c-ANCA, p-ANCA, oxLDL-ab, IgM ACA, IgG ACA, PR3-ANCA, histone-ab, SSA-ab, SSB-ab, Mit-ab) were measured, and comorbidity and disability (Katz Index of ADL) were registered. In all, 207 (75.0%) of 276 eligible subjects participated, and 148 agreed to blood tests. A large majority (79.3%) had at least one autoantibody detected. Organ specific autoantibodies were present in 32.1% of the centenarians. The high level of autoantibodies did not reflect an equally high level of overt autoimmune disease. While nonorgan specific autoantibodies were equally represented in less-disabled/disabled subjects as well as in subjects with low/high comorbidity, significantly fewer subjects with organ specific autoantibodies were found among less-disabled subjects or subjects with low comorbidity. Autoantibodies (both nonorgan and organ specific) are common in an unselected population of centenarians of today, but do not reflect an equally high level of overt autoimmune disease. Non-organ specific autoantibodies are evenly distributed irrespective of the level of disability or comorbidity, suggesting underlying, undiagnosed pathological processes which may be part of the processes involved in frailty.
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Registered trials
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