ArticleThe Biochemical journal2004
A misassembled transmembrane domain of a polytopic protein associates with signal peptide peptidase.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Topology surveillance of the lanosterol demethylase CYP51A1 by signal peptide peptidase.Journal of cell science · 2024Article
- Histocompatibility Minor 13 (HM13), targeted by miR-760, exerts oncogenic role in breast cancer by suppressing autophagy and activating PI3K-AKT-mTOR pathway.Cell death & disease · 2022Article
- Characterizing the selectivity of ER α-glucosidase inhibitors.Glycobiology · 2019Article
- Signal Peptide Peptidase, Encoded by HM13, Contributes to Tumor Progression by Affecting EGFRvIII Secretion Profiles in Glioblastoma.CNS neuroscience & therapeutics · 2017Article
- Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u.The EMBO journal · 2014Article
- Plasmodium falciparum signal peptide peptidase cleaves malaria heat shock protein 101 (HSP101). Implications for gametocytogenesis.Biochemical and biophysical research communications · 2014Article
- Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins.The Journal of cell biology · 2014Article
- Binding of HSV-1 glycoprotein K (gK) to signal peptide peptidase (SPP) is required for virus infectivity.PloS one · 2014Article
- Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity.Biochimica et biophysica acta · 2013Review
- Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Vigilin interacts with signal peptide peptidase.Proteome science · 2012Article
- The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology.Physiological reviews · 2012Review
- Post-liberation cleavage of signal peptides is catalyzed by the site-2 protease (S2P) in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Three-dimensional structure of the signal peptide peptidase.The Journal of biological chemistry · 2011Article
- Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes.The Biochemical journal · 2010Article
- Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation.The EMBO journal · 2010Article
- The signal peptide peptidase is required for pollen function in Arabidopsis.Plant physiology · 2009Article
- An internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin domain protein.The Journal of biological chemistry · 2008Article
- Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.Advances in immunology · 2006Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The endoplasmic reticulum (ER) exerts a quality control over newly synthesized proteins and a variety of components have been implicated in the specific recognition of aberrant or misfolded polypeptides. We have exploited a site-specific cross-linking approach to search for novel ER components that may specifically recognize the misassembled transmembrane domains present in truncated polytopic proteins. We find that a single probe located in the transmembrane domain of a truncated opsin fragment is cross-linked to several ER proteins. These components are distinct from subunits of the Sec61 complex and represent a 'post-translocon' environment. In this study, we identify one of these post-translocon cross-linking partners as the signal peptide peptidase (SPP). We find that the interaction of truncated opsin chains with SPP is mediated by its second transmembrane domain, and propose that this interaction may contribute to the recognition of misassembled transmembrane domains during membrane protein quality control at the ER.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.