ArticleThe EMBO journal1992
Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Extensive peripheral immunoglobulin repertoire analyses in people with multiple sclerosis reveal disease-specific signatures and distinct treatment effects of disease modifying drugs.Journal of neuroinflammation · 2026Article
- VH-replacement shapes the antibody repertoire by removing the genes of non-functional heavy-chains.The EMBO journal · 2025Article
- Marsupial Ig genomics revisited and the potential role of retroelements in the limited number of heavy chain isotypes.BMC biology · 2025Article
- Bat humoral immunity and its role in viral pathogenesis, transmission, and zoonosis.Frontiers in immunology · 2024Review
- Evolution of immunogenetic components encoding ultralong CDR H3.Immunogenetics · 2023Article
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- Tracing CLL-biased stereotyped immunoglobulin gene rearrangements in normal B cell subsets using a high-throughput immunogenetic approach.Molecular medicine (Cambridge, Mass.) · 2020Article
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- Absorbance summation: A novel approach for analyzing high-throughput ELISA data in the absence of a standard.PloS one · 2018Article
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- Antigen receptor stereotypy in chronic lymphocytic leukemia.Leukemia · 2017Review
- Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J Recombination.Cell reports · 2016Article
- V genes in primates from whole genome sequencing data.Immunogenetics · 2015Article
- Diversity of immunoglobulin lambda light chain gene usage over developmental stages in the horse.Developmental and comparative immunology · 2014Article
- Sequencing of modern Lepus VDJ genes shows that the usage of VHn genes has been retained in both Oryctolagus and Lepus that diverged 12 million years ago.Immunogenetics · 2013Article
- Developmental progression of equine immunoglobulin heavy chain variable region diversity.Developmental and comparative immunology · 2013Article
- Contribution of V(H) replacement products to the generation of anti-HIV antibodies.Clinical immunology (Orlando, Fla.) · 2013Article
- Molecular characterization of the early B cell response to pulmonary Cryptococcus neoformans infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Article
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Authors and funding
4 authors.
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Abstract
Mammalian immunoglobulin VH families can be grouped into three distinct clans based upon sequence conservation in two of the three framework (FR) intervals. Through replacement/silent site substitution analysis, molecular modeling and mathematical evaluation of known immunoglobulin crystal structures, we demonstrate that this conservation reflects preservation of protein sequence and structure. Each clan contains a characteristic FR 1 interval that is solvent-exposed and structurally separated from the antigen binding site. Families within a clan contain their own unique FR 3 interval that is capable of either influencing the conformation of the antigen binding site or interacting directly with antigen. Our results provide a structural context for theories that address differential use of VH families in the immune response.
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