ArticleThe EMBO journal1992
Enrichment and characterization of uncommitted B-cell precursors from fetal liver at day 12 of gestation.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 83 citations in OpenAlex.
- The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.Molecular and cellular biology · 2007Article
- Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A.The Journal of experimental medicine · 2004Article
- Stem cell emergence and hemopoietic activity are incompatible in mouse intraembryonic sites.The Journal of experimental medicine · 1999Article
- Commitment to the B lymphoid lineage occurs before DH-JH recombination.The Journal of experimental medicine · 1999Article
- Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12.The Journal of experimental medicine · 1998Article
- Control of B cell development by Ras-mediated activation of Raf.The EMBO journal · 1997Article
- Identification of a novel developmental stage marking lineage commitment of progenitor thymocytes.The Journal of experimental medicine · 1997Article
- Potential intraembryonic hemogenic sites at pre-liver stages in the mouse.Anatomy and embryology · 1995Article
- Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Differentiation and characterization of B-cell precursors detected in the yolk sac and embryo body of embryos beginning at the 10- to 12-somite stage.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Emergence of committed B lymphoid progenitors in the developing chicken embryo.The EMBO journal · 1992Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe an assay system that allows precursor cells, uncommitted for heavy and light chain immunoglobulin expression, to develop into B lymphocytes that can differentiate to antibody-producing cells. Some precursors have the immunoglobulin loci in germ-line configuration. Approximately 200-1500 precursor cells are present in one fetal liver by day 12 of gestation; they express the surface marker AA4.1. Most precursors do not express the B220 marker. Commitment to heavy chain immunoglobulin expression occurs after an average of two cell division; commitment to light chain expression takes place after two additional rounds of division. DNA analysis from the progeny of single precursor cells shows that: (i) most B220- precursor cells have not completed D-J rearrangement (9/11) and some were in germ line configuration (4/11); and (ii) most B220+ precursor cells exhibit two D-J rearrangements (4/5 samples). These experiments define two types of B-lymphocyte precursor cells in fetal liver: the first, B220+ AA4.1+, acquires the capacity to respond to mitogens only after 5 days in culture, and does not have productive V-D-J rearrangements but might exhibit two stable D-J rearrangements; the second, B220- AA4.1+, acquires the capacity to respond to mitogens only after 9 days in culture and can be in germ-line configuration in the Ig loci, and undergoes rearrangement of heavy and light chain genes in vitro. Both precursor types require interaction with stromal cells before becoming responsive to interleukin 7.
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