ArticleThe EMBO journal1992
Molecular cloning and characterization of an interferon induced human cDNA with sequence homology to a mammalian peptide chain release factor.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- Gene expression in chronic granulomatous disease and interferon-γ receptor-deficient cells treated in vitro with interferon-γ.Journal of cellular biochemistry · 2019Article
- Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons.Molecular and cellular biology · 1996Article
- The "eRF" clone corresponds to tryptophanyl-tRNA synthetase, not mammalian release factor.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Mammalian polypeptide chain release factor and tryptophanyl-tRNA synthetase are distinct proteins.The EMBO journal · 1993Article
- The response of gamma interferon activation factor is under developmental control in cells of the macrophage lineage.Molecular and cellular biology · 1993Article
- The yeast nuclear gene MRF1 encodes a mitochondrial peptide chain release factor and cures several mitochondrial RNA splicing defects.Nucleic acids research · 1992Article
- Depletion of tryptophan is not involved in expression of tryptophanyl-tRNA synthetase mediated by interferon.Infection and immunity · 1992Article
- Sequence comparison of new prokaryotic and mitochondrial members of the polypeptide chain release factor family predicts a five-domain model for release factor structure.Nucleic acids research · 1992Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we report the molecular cloning of several related human cDNAs from which a full-length sequence can be determined. The cDNAs encode a 2.8 kb mRNA that is strongly induced by interferon (IFN) gamma and the expression of which is not cell-restricted but observed in fibroblasts, macrophages and epithelial cells. The deduced amino acid sequence predicts a protein of 471 amino acids with high sequence similarity to a previously identified rabbit peptide chain release factor. Functional studies to demonstrate release factor activity showed that the protein encoded by this cDNA inhibited the readthrough activity of a yeast UGA suppressor tRNA in an in vitro translation system. The identification of this novel cDNA implies that translational control by IFN induced proteins may not be restricted to the initial steps of protein synthesis but may also act by regulation of peptide chain termination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.