ArticleThe Journal of clinical investigation2004
Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP.
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 115 citations in OpenAlex.
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- Mental and Body Health: The Association between Psychological Factors, Overweight, and Blood Pressure in Young Adults.Journal of clinical medicine · 2022Article
- An Outline of Renal Artery Stenosis Pathophysiology-A Narrative Review.Life (Basel, Switzerland) · 2021Review
- Inflammation-linked adaptations in dermal microvascular reactivity accompany the development of obesity and type 2 diabetes.International journal of obesity (2005) · 2019Article
- Apolipoprotein E favours the blunting by high-fat diet of prostacyclin receptor activation in the mouse aorta.British journal of pharmacology · 2018Article
- Interactions between the Cyclooxygenase Metabolic Pathway and the Renin-Angiotensin-Aldosterone Systems: Their Effect on Cardiovascular Risk, from Theory to the Clinical Practice.BioMed research international · 2018Review
- Long Lasting Microvascular Tone Alteration in Rat Offspring Exposed In Utero to Maternal Hyperglycaemia.PloS one · 2016Article
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- Association between anxiety and hypertension: a systematic review and meta-analysis of epidemiological studies.Neuropsychiatric disease and treatment · 2015Article
- Prostacyclin synthase: upregulation during renal development and in glomerular disease as well as its constitutive expression in cultured human mesangial cells.Mediators of inflammation · 2015Article
- Nonatherosclerotic obstructive vascular diseases of the mesenteric and renal arteries.Clinical cardiology · 2014Review
- Classical Renin-Angiotensin system in kidney physiology.Comprehensive Physiology · 2014Review
- Regulation of renin release via cyclic ADP-ribose-mediated signaling: evidence from mice lacking CD38 gene.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2013Article
- Physiologic and pathophysiologic roles of cyclooxygenase-2 in the kidney.Transactions of the American Clinical and Climatological Association · 2013Article
- Eplerenone inhibits aldosterone-induced renal expression of cyclooxygenase.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2012Article
- Synthesis and secretion of renin in mice with induced genetic mutations.Kidney international · 2012Review
- Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.Clinical and experimental nephrology · 2012Review
- iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling.PloS one · 2012Article
- A major role for the EP4 receptor in regulation of renin.American journal of physiology. Renal physiology · 2011Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent reduction of renal perfusion pressure induces renovascular hypertension by activating the renin-angiotensin-aldosterone system; however, the sensing mechanism remains elusive. Here we investigated the role of PGI2 in renovascular hypertension in vivo, employing mice lacking the PGI2 receptor (IP-/- mice). In WT mice with a two-kidney, one-clip model of renovascular hypertension, the BP was significantly elevated. The increase in BP in IP-/- mice, however, was significantly lower than that in WT mice. Similarly, the increases in plasma renin activity, renal renin mRNA, and plasma aldosterone in response to renal artery stenosis were all significantly lower in IP-/- mice than in WT mice. All these parameters were measured in mice lacking the four PGE2 receptor subtypes individually, and we found that these mice had similar responses to WT mice. PGI2 is produced by COX-2 and a selective inhibitor of this enzyme, SC-58125, also significantly reduced the increases in plasma renin activity and renin mRNA expression in WT mice with renal artery stenosis, but these effects were absent in IP-/- mice. When the renin-angiotensin-aldosterone system was activated by salt depletion, SC-58125 blunted the response in WT mice but not in IP-/- mice. These results indicate that PGI2 derived from COX-2 plays a critical role in regulating the release of renin and consequently renovascular hypertension in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.