ReviewThe Journal of clinical investigation2004
Prostanoids and blood pressure: which way is up?
Review in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Association between acetaminophen administration and outcomes in critically ill patients with gout and hypertension.Frontiers in pharmacology · 2024Article
- Cell-Specific Actions of the Prostaglandin E-Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages.Journal of the American Heart Association · 2022Article
- Novel Evidence-Based Combination of Plant Extracts with Multitarget Mechanisms of Action for the Elimination of Hot Flashes during Menopause.Molecules (Basel, Switzerland) · 2022Article
- EP3 Receptor Deficiency Improves Vascular Remodeling and Cognitive Impairment in Cerebral Small Vessel Disease.Aging and disease · 2022Article
- Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury.Kidney international · 2022Article
- The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs.Trends in pharmacological sciences · 2017Review
- Classical Renin-Angiotensin system in kidney physiology.Comprehensive Physiology · 2014Review
- 11β-Hydroxysteroid Dehydrogenase Type II is a Potential Target for Prevention of Colorectal Tumorigenesis.Journal of oncobiomarkers · 2013Article
- Comorbidity profile among patients with rheumatoid arthritis and the impact on prescriptions trend.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2013Article
- Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis.European journal of human genetics : EJHG · 2011Article
- The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.Hypertension (Dallas, Tex. : 1979) · 2010Article
- Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney.The Journal of clinical investigation · 2008Article
- Omega-3 polyunsaturated fatty acids: Their potential role in blood pressure prevention and management.Heart international · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of the family of prostanoids, made up of prostaglandins and thromboxanes, are generated via COX-mediated metabolism of arachidonic acid. These lipid mediators exhibit wide-ranging biological actions that include regulating both vasomotor tone and renal sodium excretion. As COX inhibition is often associated with sodium retention leading to edema and hypertension, prostanoids appear to have a role in preventing the development of high blood pressure. On the other hand, prostaglandin E2 (PGE2) and PGI2 have also been implicated as determinants of renin secretion. A new study suggests that PGI2 plays a critical role in stimulating renin release and promoting hypertension following renal artery stenosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.