ArticleThe EMBO journal2004
An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion.
Article in The EMBO journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Elucidation of the Roles of CD22 Cis-Ligands in B Lymphocyte Development and Signaling Using Genetic and Chemical Tools.Advances in experimental medicine and biology · 2026Review
- Nerve Growth Factor and Autoimmune Diseases.Current issues in molecular biology · 2023Review
- PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III.Experimental & molecular medicine · 2023Article
- NF-kB's contribution to B cell fate decisions.Frontiers in immunology · 2023Review
- Nuclear Inositides and Inositide-Dependent Signaling Pathways in Myelodysplastic Syndromes.Cells · 2020Review
- Rescue of hematopoietic stem/progenitor cells formation in plcg1 zebrafish mutant.Scientific reports · 2019Article
- A PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex.Journal of proteome research · 2017Article
- Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1.PloS one · 2015Article
- Phospholipase Cγ2 plays a role in TCR signal transduction and T cell selection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.The Journal of experimental medicine · 2009Article
- Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis.The Journal of biological chemistry · 2008Article
- Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1.PloS one · 2008Article
- Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.The Journal of cell biology · 2007Article
- Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.Molecular and cellular biology · 2007Article
- Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation.Molecular and cellular biology · 2007Article
- Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.Molecular and cellular biology · 2006Article
- Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Phospholipase Cgamma1 (PLCgamma1) has been reported to be expressed predominantly in T cells and to play an important role in T-cell receptor signaling. Here we show that PLCgamma1 is expressed throughout B-cell development, with high expression in B-cell progenitors, and is involved in pre-B-cell receptor (pre-BCR) signaling. Reduced expression of PLCgamma1, in the absence of PLCgamma2 (PLCgamma1+/-PLCgamma2-/-), impedes early B-cell development at the pro-B- to pre-B-cell transition and impairs immunoglobulin heavy chain allelic exclusion, hallmarks of defective pre-BCR signaling. In contrast, early B-cell development is largely normal, whereas late B-cell maturation is impaired in the absence of PLCgamma2 alone (PLCgamma2-/-) and overexpression of PLCgamma1 in PLCgamma2-/- mice fails to restore BCR-mediated B-cell proliferation and maturation. These studies reveal an essential role of PLCgamma1, distinct from that of PLCgamma2, in B-cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.