ReviewGenes and immunity2004
Genetic analysis of innate immunity in resistance to Candida albicans.
Review in Genes and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- The Contribution of Human Antimicrobial Peptides to Fungi.International journal of molecular sciences · 2025Review
- Commentary: Experimental Mouse Models of Invasive Candidiasis Caused byJournal of cellular immunology · 2022Article
- Histatin 5 Metallopeptides and Their Potential againstBiomolecules · 2021Review
- Renal CD169Life science alliance · 2021Article
- Article
- Effects of immune suppression in murine models of disseminated Candida glabrata and Candida tropicalis infection and utility of a synthetic peptide vaccine.Medical mycology · 2019Article
- Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.Nature immunology · 2019Article
- Influenza Pathogenesis in Genetically Defined Resistant and Susceptible Murine Strains .The Yale journal of biology and medicine · 2017Review
- Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Article
- The β-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance.Cell host & microbe · 2011Article
- Article
- Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium.Experimental parasitology · 2010Article
- Efficient and rapid identification of Candida albicans allelic status using SNP-RFLP.FEMS yeast research · 2009Article
- Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Cardiac failure in C5-deficient A/J mice after Candida albicans infection.Infection and immunity · 2006Article
- A drug-sensitive genetic network masks fungi from the immune system.PLoS pathogens · 2006Article
- Genetic control of susceptibility to Candida albicans in susceptible A/J and resistant C57BL/6J mice.Genes and immunity · 2005Article
- Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic candidiasis is a significant cause of nosocomial infections and the mechanisms of defense against Candida albicans in humans remain poorly understood. Studies in animal models have demonstrated the importance of innate immunity in controlling the response to infection. Although Th1 cytokines have been shown to direct the overall outcome of infection, the precise role of the Th1/Th2 response and, more generally, the adaptive immune response as a whole, in systemic candidiasis, appears to apply mainly to the development of resistance to reinfection. A genetic approach to the identification of host factors regulating pathogenesis and susceptibility to C. albicans infection has been used in humans and in mouse models of infection. Mouse mutants bearing experimentally induced mutations in specific genes have provided a systematic tool for directly assessing the role of individual proteins in C. albicans susceptibility. Inbred mouse strains have been valuable in showcasing the spectrum of naturally occurring variations in initial susceptibility to infection, and type of disease developed. Crosses between resistant and susceptible strains have led to the detection of additional gene effects affecting innate immunity. Of particular interest is the major effect of a naturally occurring loss-of-function mutation in the C5 complement component that has become fixed in many inbred strains. These and other studies have shown that both a functional complement pathway and robust inflammatory response are critical for resistance to C. albicans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.