ArticleJournal of perinatology : official journal of the California Perinatal Association2004
Cardiopulmonary resuscitation and epinephrine infusion in extremely low birth weight infants in the neonatal intensive care unit.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Extensive cardiopulmonary resuscitation for VLBW and ELBW infants: a systematic review and meta-analyses.Journal of perinatology : official journal of the California Perinatal Association · 2009Pooled it
- An Update on Pharmacologic Management of Neonatal Hypotension: When, Why, and Which Medication.Children (Basel, Switzerland) · 2024Review
- Cardiopulmonary resuscitation of infants at birth: predictable or unpredictable?Acute and critical care · 2022Article
- Efficacy of Low-Dose Epinephrine Continuous Infusion in Neonatal Intensive Care Unit Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- Incidence, characteristics, and survival following cardiopulmonary resuscitation in the quaternary neonatal intensive care unit.Resuscitation · 2017Article
- Cardiopulmonary resuscitation in hospitalized infants.Early human development · 2016Observational
- Too much of a good thing? Epinephrine on trial!Journal of perinatology : official journal of the California Perinatal Association · 2005Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurvival of extremely low birth weight (ELBW) infants has improved significantly; however, the aggressiveness of treatment in these infants remains controversial. Critical appraisal of the benefits of cardiopulmonary resuscitation (CPR) and intravenous epinephrine infusion (IV EPI) has not been studied in this population.
objectiveTo determine if either CPR or continuous IV EPI in NICU is of benefit for surviving in a selected population of infants weighing </=750 g birthweight.
methodsCase records of infants </=750 g birthweight were reviewed retrospectively to document episodes of CPR and the use of IV EPI for inotropic support. Demographic data were collected for each infant and severity of illness scores were calculated using the clinical risk index for babies (CRIB).
resultsIn all, 91 infants </=750 g birth weight were identified, the overall survival rate was 35/91 (38%). A total of 15 infants received CPR, none of these infants survived to discharge. A total of 47 infants received continuous IV EPI of which 10/47 survived in comparison to 25/44 infants who did not receive this treatment (p<0.001). Increasing dosage of IV EPI was associated with decreased survival. All infants who received epinephrine at a dose >1.0 mcg/kg/hour intravenously died.
conclusionsIn view of the poor survival after either CPR or high-dose IV EPI in infants </=750 g, extreme caution should be applied to the use of these therapies in this high-risk population of ELBW infants.
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