ArticleMolecular biology of the cell2004
Multivesicular body-ESCRT components function in pH response regulation in Saccharomyces cerevisiae and Candida albicans.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed.
- Fungal biofilm formation and its regulatory mechanism.Heliyon · 2024Review
- Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species.Antioxidants (Basel, Switzerland) · 2024Article
- Alkaliphilic/Alkali-Tolerant Fungi: Molecular, Biochemical, and Biotechnological Aspects.Journal of fungi (Basel, Switzerland) · 2023Review
- Candida albicans Hyphal Morphogenesis within Macrophages Does Not Require Carbon Dioxide or pH-Sensing Pathways.Infection and immunity · 2023Article
- Lithium chloride sensitivity connects the activity of PEX11 and RIM20 to the translation of PGM2 and other mRNAs with structured 5'-UTRs.Molecular and cellular biochemistry · 2022Article
- The Role of Exosome and the ESCRT Pathway on Enveloped Virus Infection.International journal of molecular sciences · 2021Review
- The enigma of environmental pH sensing in plants.Nature plants · 2021Review
- Role of the ESCRT Pathway in Laccase Trafficking and Virulence of Cryptococcus neoformans.Infection and immunity · 2020Article
- The ESCRT System Plays an Important Role in the Germination in Candida albicans by Regulating the Expression of Hyphal-Specific Genes and the Localization of Polarity-Related Proteins.Mycopathologia · 2020Article
- ESCRT-III and ER-PM contacts maintain lipid homeostasis.Molecular biology of the cell · 2020Article
- Identification and characterization of a protein Bro1 essential for sophorolipids synthesis in Starmerella bombicola.Journal of industrial microbiology & biotechnology · 2020Article
- The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020Review
- Interactions in the ESCRT-III network of the yeast Saccharomyces cerevisiae.Current genetics · 2019Article
- Aggregate Filamentous Growth Responses in Yeast.mSphere · 2019Article
- A resource of variant effect predictions of single nucleotide variants in model organisms.Molecular systems biology · 2018Article
- Going with the Flo: The Role of Flo11-Dependent and Independent Interactions in Yeast Mat Formation.Journal of fungi (Basel, Switzerland) · 2018Review
- Characterization of additional components of the environmental pH-sensing complex in the pathogenic fungusThe Journal of biological chemistry · 2018Article
- The Plant Defensin NaD1 Enters the Cytoplasm of Candida Albicans via Endocytosis.Journal of fungi (Basel, Switzerland) · 2018Article
- Compensatory Internalization of Pma1 in V-ATPase Mutants inGenetics · 2018Article
- Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.Oxidative medicine and cellular longevity · 2018Review
39 more citing papers are in PubMed but not listed here.
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4 authors.
Funding
Abstract
The ESCRT-I, -II, and -III protein complexes function to create multivesicular bodies (MVBs) for sorting of proteins destined for the lysosome or vacuole. Prior studies with Saccharomyces cerevisiae have shown that the ESCRT-III protein Snf7p interacts with the MVB pathway protein Bro1p as well as its homolog Rim20p. Rim20p has no role in MVB formation, but functions in the Rim101p pH-response pathway; Rim20p interacts with transcription factor Rim101p and is required for the activation of Rim101p by C-terminal proteolytic cleavage. We report here that ESCRT-III proteins Snf7p and Vps20p as well as all ESCRT-I and -II proteins are required for Rim101p proteolytic activation in S. cerevisiae. Mutational analysis indicates that the Rim20p N-terminal region interacts with Snf7p, and an insertion in the Rim20p "Bro1 domain" abolishes this interaction, as determined with two-hybrid assays. Disruption of the MVB pathway through mutations affecting non-ESCRT proteins does not impair Rim101p processing. The relationship between the MVB pathway and Rim101p pathway is conserved in Candida albicans, because mutations in four ESCRT subunit genes abolish alkaline pH-induced filamentation, a phenotype previously seen for rim101 and rim20 mutants. The defect is suppressed by expression of C-terminally truncated Rim101-405p, as expected for mutations that block Rim101p proteolytic activation. These results indicate that the ESCRT complexes govern a specific signal transduction pathway and suggest that the MVB pathway may provide a signal that regulates pH-responsive transcription.
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