ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it, 299 citations in OpenAlex.
- Effects of ketamine on fear memory extinction: a review of preclinical literature.Frontiers in neuroscience · 2025Pooled it
- Cortisol suppression impairs retrieval of emotional memory and changes its neural correlates immediately and four days post-treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Menstrual cycle effects on cortisol responsivity and emotional retrieval following a psychosocial stressor.Hormones and behavior · 2015Trial
- Concurrent glucocorticoid and noradrenergic activity shifts instrumental behavior from goal-directed to habitual control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Trial
- Stress enhances retrieval of drug-related memories in abstinent heroin addicts.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Trial
- Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity.Psychopharmacology · 2007Trial
- Functional loss of PKMζ in the dorsal hippocampus potentiates the time-dependent increase in false contextual fear memory and impairs spatial recognition memory in mice.Frontiers in behavioral neuroscience · 2026Article
- Corticosterone after early adolescent stress prevents social avoidance, aversive behavior, and morphine-conditioned place preference in adulthood.Psychopharmacology · 2024Article
- The cognitive impact of light: illuminating ipRGC circuit mechanisms.Nature reviews. Neuroscience · 2024Review
- Coping with the multifaceted and multifunctional role of cortisol in the brain.Neuroscience applied · 2024Review
- Time-course analysis of frontal gene expression profiles in the rat model of posttraumatic stress disorder and a comparison with the conditioned fear model.Neurobiology of stress · 2023Article
- Inhibitory Metaplasticity in Juvenile Stressed Rats Restores Associative Memory in Adulthood by Regulating Epigenetic Complex G9a/GLP.The international journal of neuropsychopharmacology · 2022Article
- Propranolol for the management of behavioural and psychological symptoms of dementia.Drugs in context · 2022Review
- The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder.Current addiction reports · 2022Review
- The Pathways between Cortisol-Related Regulation Genes and PTSD Psychotherapy.Healthcare (Basel, Switzerland) · 2020Review
- Central norepinephrine transmission is required for stress-induced repetitive behavior in two rodent models of obsessive-compulsive disorder.Psychopharmacology · 2020Article
- Nightmares and the Cannabinoids.Current neuropharmacology · 2020Review
- Across time and space: spatial-temporal binding under stress.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- The effects of post-encoding stress and glucocorticoids on episodic memory in humans and rodents.Brain and cognition · 2019Review
- Top-down and bottom-up control of stress-coping.Journal of neuroendocrinology · 2019Review
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Previous findings indicate that administration of abeta-adrenoceptor antagonist systemically blocks glucocorticoid impairment of memory retrieval. Here, we report that beta-adrenoceptor activation in the hippocampus and the basolateral complex of the amygdala (BLA) is implicated in the impairing effects of glucocorticoids on memory retrieval. The specific glucocorticoid receptor (GR) agonist 11beta,17beta-dihydroxy-6,21-dimethyl-17alpha-pregna-4,6-trien-20yn-3-one (RU 28362) (15 ng) infused into the hippocampus of male Sprague Dawley rats 60 min before water maze retention testing, 24 hr after training, impaired probe trial retention performance, as assessed by quadrant search time and initial latency to cross the platform location. Because we found previously that RU 28362 infused into the hippocampus does not affect water maze acquisition or immediate recall, the findings suggest that the GR agonist-induced retention impairment was attributable to a selective influence on long-term memory retrieval. Likewise, systemic injections of the beta1-adrenoceptor partial agonist xamoterol (3.0 or 10.0 mg/kg, s.c.) 60 min before the probe trial dose-dependently impaired retention performance. The beta-adrenoceptor antagonist propranolol (2.0 mg/kg) administered subcutaneously before retention testing did not affect retention performance alone, but blocked the memory retrieval impairment induced by concurrent intrahippocampal infusions of RU 28362. Pretest infusions of the beta1-adrenoceptor antagonist atenolol into either the hippocampus (1.25 microg in 0.5 microl) or the BLA (0.5 microg in 0.2 microl) also prevented the GR agonist-induced memory retrieval impairment. These findings suggest that glucocorticoids impair retrieval of long-term spatial memory by facilitating noradrenergic mechanisms in the hippocampus, and additionally, that norepinephrine-mediated BLA activity is critical in enabling hippocampal glucocorticoid effects on memory retrieval.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.