ArticleGenetics2005
Core promoter sequences contribute to ovo-B regulation in the Drosophila melanogaster germline.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A mdg4 retrotransposon screen for X-linked female sterile alleles and its relationship with the transcription factor OVO.G3 (Bethesda, Md.) · 2026Article
- AbioRxiv : the preprint server for biology · 2026Article
- Review
- Female germline expression of OVO transcription factor bridges Drosophila generations.G3 (Bethesda, Md.) · 2025Article
- Transcriptional regulation of the piRNA pathway by Ovo in animal ovarian germ cells.Genes & development · 2025Article
- OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in theeLife · 2024Article
- Diverse somatic Transformer and sex chromosome karyotype pathways regulate gene expression in Drosophila gonad development.bioRxiv : the preprint server for biology · 2024Article
- OVO Positively Regulates Essential Maternal Pathways by Binding Near the Transcriptional Start Sites in thebioRxiv : the preprint server for biology · 2024Article
- CRISPR Disruption ofInsects · 2019Article
- A truncated form of a transcription factor Mamo activatesCommunications biology · 2019Article
- Reprogramming of regulatory network using expression uncovers sex-specific gene regulation in Drosophila.Nature communications · 2018Article
- Conserved role of Ovo in germline development in mouse and Drosophila.Scientific reports · 2017Article
- Comparative validation of the D. melanogaster modENCODE transcriptome annotation.Genome research · 2014Article
- Genome-wide computational prediction and analysis of core promoter elements across plant monocots and dicots.PloS one · 2013Article
- Drosophila germline sex determination: integration of germline autonomous cues and somatic signals.Current topics in developmental biology · 2008Article
- Global analysis of X-chromosome dosage compensation.Journal of biology · 2006Article
- Comparative genomics of Drosophila and human core promoters.Genome biology · 2006Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Utilization of tightly linked ovo-A vs. ovo-B germline promoters results in the expression of OVO-A and OVO-B, C(2)H(2) transcription factors with different N -termini, and different effects on target gene transcription and on female germline development. We show that two sex-determination signals, the X chromosome number within the germ cells and a female soma, differentially regulate ovo-B and ovo-A. We have previously shown that OVO regulates ovarian tumor transcription by binding the transcription start site. We have explored the regulation of the ovo-B promoter using an extensive series of transgenic reporter gene constructs to delimit cis-regulatory sequences as assayed in wild-type and sex-transformed flies and flies with altered ovo dose. Minimum regulated expression of ovo-B requires a short region flanking the transcription start site, suggesting that the ovo-B core promoter bears regulatory information in addition to a "basal" activity. In support of this idea, the core promoter region binds distinct factors in ovary and testis extracts, but not in soma extracts, suggesting that regulatory complexes form at the start site. This idea is further supported by the evolutionarily conserved organization of OVO binding sites at or near the start sites of ovo loci in other flies.
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