ArticleMolecular and cellular biology2004
beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Plakoglobin does not participate in endothelial barrier stabilization mediated by cAMP.Scientific reports · 2025Article
- Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures.Frontiers in cell and developmental biology · 2020Article
- Modification of cysteine 457 in plakoglobin modulates the proliferation and migration of colorectal cancer cells by altering binding to E-cadherin/catenins.Redox report : communications in free radical research · 2017Article
- The clinical significance of γ-catenin in acute myeloid leukemia.OncoTargets and therapy · 2016Article
- Beta-Catenin and Plakoglobin Expression during Zebrafish Tooth Development and Replacement.PloS one · 2016Article
- Plakoglobin as a regulator of desmocollin gene expression.The Journal of investigative dermatology · 2013Article
- Wnt signaling in skin development, homeostasis, and disease.Cold Spring Harbor perspectives in biology · 2013Review
- Wnt/beta-catenin signaling and small molecule inhibitors.Current pharmaceutical design · 2013Review
- Plakoglobin: role in tumorigenesis and metastasis.International journal of cell biology · 2012Article
- Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation.Nature cell biology · 2011Article
- Desmosomes: new perpetrators in tumour suppression.Nature reviews. Cancer · 2011Review
- Diverse mechanisms of Wnt activation and effects of pathway inhibition on proliferation of human gastric carcinoma cells.Oncogene · 2011Article
- Plakoglobin regulates cell motility through Rho- and fibronectin-dependent Src signaling.Journal of cell science · 2010Article
- Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis.The Journal of cell biology · 2009Article
- Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin.The EMBO journal · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both beta-catenin and plakoglobin can stimulate the expression of Lef/Tcf target genes in vitro. beta-Catenin is known to associate with Lef/Tcf factors and to participate directly in transactivation in vivo, whereas the role of plakoglobin in transcriptional regulation has been less studied. To analyze the functions of plakoglobin in vivo, we generated transgenic mice expressing in the epidermis N-terminally truncated plakoglobin (DeltaN122-PG) lacking the glycogen synthase kinase 3beta phosphorylation sites and therefore protected against degradation (transgenic line K5-DeltaN122-PG). The expression of DeltaN122-PG led to the formation of additional hair germs, hyperplastic hair follicles, and noninvasive hair follicle tumors, a phenotype reminiscent of that induced by expression of N-terminally truncated beta-catenin. However, if expressed in beta-catenin-null epidermis, DeltaN122-PG did not induce new hair follicle germs and follicular tumors. Thus, DeltaN122-PG cannot substitute for beta-catenin in its signaling functions in vivo and the phenotype observed in K5-DeltaN122-PG mouse skin must be due to the aberrant activation of beta-catenin signaling. On the other hand, the expression of DeltaN122-PG in beta-catenin-null skin significantly increased the survival rate of mutant mice, rescued differentiation, and limited excessive proliferation in the interfollicular epidermis, suggesting that plakoglobin may be involved in the intracellular signaling events essential for epidermal differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.