ArticleMolecular and cellular biology2004
Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Homeodomain Involvement in Nuclear HOX Protein Homo- and Heterodimerization.International journal of molecular sciences · 2025Article
- Variations in the poly-histidine repeat motif of HOXA1 contribute to bicuspid aortic valve in mouse and zebrafish.Nature communications · 2023Article
- Diversification and Functional Evolution of HOX Proteins.Frontiers in cell and developmental biology · 2022Review
- HOXA1 Is an Antagonist of ERα in Breast Cancer.Frontiers in oncology · 2021Article
- Hindbrain induction and patterning during early vertebrate development.Cellular and molecular life sciences : CMLS · 2019Review
- Mouse fitness measures reveal incomplete functional redundancy of Hox paralogous group 1 proteins.PloS one · 2017Article
- HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-κB pathway in a transcription-independent manner.Nucleic acids research · 2016Article
- Fitness Assays Reveal Incomplete Functional Redundancy of the HoxA1 and HoxB1 Paralogs of Mice.Genetics · 2015Article
- Generating spinal motor neuron diversity: a long quest for neuronal identity.Cellular and molecular life sciences : CMLS · 2014Review
- Hox transcription factors influence motoneuron identity through the integrated actions of both homeodomain and non-homeodomain regions.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Disentangling the many layers of eukaryotic transcriptional regulation.Annual review of genetics · 2012Review
- Hox proteins display a common and ancestral ability to diversify their interaction mode with the PBC class cofactors.PLoS biology · 2012Article
- Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.Developmental cell · 2011Article
- Selection of distinct Hox-Extradenticle interaction modes fine-tunes Hox protein activity.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Web-based analysis of the mouse transcriptome using Genevestigator.BMC bioinformatics · 2006Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Homeodomain containing transcription factors of the Hox family play critical roles in patterning the anteroposterior embryonic body axis, as well as in controlling several steps of organogenesis. Several Hox proteins have been shown to cooperate with members of the Pbx family for the recognition and activation of identified target enhancers. Hox proteins contact Pbx via a conserved hexapeptide motif. Previous biochemical studies provided evidence that critical amino acid substitutions in the hexapeptide sequence of Hoxa1 abolish its interaction with Pbx. As a result, these substitutions also abolish Hoxa1 activity on known target enhancers in cellular models, suggesting that Hoxa1 activity relies on its capacity to interact with Pbx. Here, we show that mice with mutations in the Hoxa1 hexapeptide display hindbrain, cranial nerve, and skeletal defects highly reminiscent of those reported for the Hoxa1 loss of function. Since similar hexapeptide mutations in the mouse Hoxb8 and the Drosophila AbdA proteins result in activity modulation and gain of function, our data demonstrate that the functional importance of the hexapeptide in vivo differs according to the Hox proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.