ArticleMolecular and cellular biology2004
Target gene-specific modulation of myocardin activity by GATA transcription factors.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Induction of human cardiomyocyte-like cells from fibroblasts by defined factors.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Transcription factor GATA6 promotes migration of human coronary artery smooth muscle cellsFrontiers in physiology · 2022Article
- NF-κB and GATA-Binding Factor 6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy.The American journal of pathology · 2019Article
- Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition.Cell death and differentiation · 2018Article
- Regulation of cardiac myocyte cell death and differentiation by myocardin.Molecular and cellular biochemistry · 2018Review
- Transdifferentiation of Fibroblasts by Defined Factors.Cellular reprogramming · 2015Review
- Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition.Science signaling · 2015Article
- Myocardin in biology and disease.Journal of biomedical research · 2015Review
- Arp5 is a key regulator of myocardin in smooth muscle cells.The Journal of cell biology · 2014Article
- GATA-6 and NF-κB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction.Molecular and cellular biology · 2013Article
- In search of novel targets for heart disease: myocardin and myocardin-related transcriptional cofactors.Biochemistry research international · 2012Article
- ZFP260 is an inducer of cardiac hypertrophy and a nuclear mediator of endothelin-1 signaling.The Journal of biological chemistry · 2011Article
- Article
- The BMP pathway acts to directly regulate Tbx20 in the developing heart.Development (Cambridge, England) · 2010Article
- Linking actin dynamics and gene transcription to drive cellular motile functions.Nature reviews. Molecular cell biology · 2010Review
- Phosphorylation of myocardin by extracellular signal-regulated kinase.The Journal of biological chemistry · 2009Article
- A rare human sequence variant reveals myocardin autoinhibition.The Journal of biological chemistry · 2008Article
- Re-employment of developmental transcription factors in adult heart disease.Seminars in cell & developmental biology · 2007Review
- Myocardin sumoylation transactivates cardiogenic genes in pluripotent 10T1/2 fibroblasts.Molecular and cellular biology · 2007Article
- Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues.American journal of physiology. Cell physiology · 2006Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocardin is a transcriptional coactivator that regulates cardiac and smooth muscle gene expression by associating with serum response factor. We show that GATA transcription factors can either stimulate or suppress the transcriptional activity of myocardin, depending on the target gene. Modulation of myocardin activity by GATA4 is mediated by the physical interaction of myocardin with the DNA binding domain of GATA4 but does not require binding of GATA4 to DNA. Paradoxically, the transcription activation domain of GATA4 is dispensable for the stimulatory effect of GATA4 on myocardin activity but is required for repression of myocardin activity. The ability of GATA transcription factors to modulate myocardin activity provides a potential mechanism for fine tuning the expression of serum response factor target genes in a gene-specific manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.