ArticleMolecular and cellular biology2004
Phosphorylation of serine 239 of Groucho/TLE1 by protein kinase CK2 is important for inhibition of neuronal differentiation.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 63 citations in OpenAlex.
- The Role of Protein Kinase CK2 in Development and Disease Progression: A Critical Review.Journal of developmental biology · 2022Review
- Roles of transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation.Frontiers in cell and developmental biology · 2022Review
- The prognostic role of the Transducin-like Enhancer of split protein family in lung adenocarcinoma.Translational lung cancer research · 2021Article
- Elucidating the pathogenic and biomarker potentials of FOXG1 in glioblastoma.Oncology reviews · 2020Article
- Groucho related gene 5 (GRG5) is involved in embryonic and neural stem cell state decisions.Scientific reports · 2018Article
- Characterization of a FOXG1:TLE1 transcriptional network in glioblastoma-initiating cells.Molecular oncology · 2018Article
- Epigenetic modification of TLE1 induce abnormal differentiation in diabetic mice intestinal epithelium.Molecular and cellular biochemistry · 2018Article
- TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression.Oncotarget · 2017Article
- Protein kinase CK2 in development and differentiation.Biomedical reports · 2017Article
- Unraveling the differential dynamics of developmental fate in central and peripheral nervous systems.Scientific reports · 2016Article
- A mutation of casein kinase 2 α4 subunit affects multiple developmental processes in Arabidopsis.Plant cell reports · 2016Article
- Characterization of Aes nuclear foci in colorectal cancer cells.Journal of biochemistry · 2016Article
- The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub.The Journal of biological chemistry · 2015Article
- The Groucho/Transducin-like enhancer of split protein family in animal development.IUBMB life · 2015Review
- O-GlcNAc transferase is critical for transducin-like enhancer of split (TLE)-mediated repression of canonical Wnt signaling.The Journal of biological chemistry · 2014Article
- Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation.Cell death and differentiation · 2014Article
- Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.Molecular and cellular biology · 2013Article
- Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth.Nature communications · 2013Article
- Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead box protein G1 (FoxG1) to promote neuronal survival.The Journal of biological chemistry · 2012Article
- Hes-1 regulates the excitatory fate of neural progenitors through modulation of Tlx3 (HOX11L2) expression.Cellular and molecular life sciences : CMLS · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcriptional corepressors of the Groucho (Gro)/TLE family play important roles during a variety of developmental pathways, including neuronal differentiation. In particular, they act as negative regulators of neurogenesis, together with Hairy/Enhancer of split (Hes) DNA-binding proteins. The interaction with Hes1 leads to Gro/TLE hyperphosphorylation and increased transcription repression activity in mammalian cells, but the underlying molecular mechanisms are poorly characterized. We now show that Gro/TLE1 is phosphorylated in vivo by protein kinase CK2. This phosphorylation occurs at serine 239 within the conserved CcN domain present in all Gro/TLE family members. Mutation of serine 239 into alanine decreases Hes1-induced hyperphosphorylation of Gro/TLE1 and also reduces its nuclear association and transcription repression activity. We demonstrate further that Gro/TLE1 inhibits the transition of cortical neural progenitors into neurons and that its antineurogenic activity is inhibited by a serine-239-alanine mutation but not by a serine-239-glutamate mutation. These results suggest that CK2 phosphorylation of serine 239 of Gro/TLE1 is important for its function during neuronal differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.