ArticleJournal of virology2004
Cell fusion activities of Hantaan virus envelope glycoproteins.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- Pathogenicity and virulence of Rodent-Borne Orthohantaviruses.Virulence · 2025Review
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- Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic target.Scientific reports · 2021Article
- Self-association and subcellular localization of Puumala hantavirus envelope proteins.Scientific reports · 2019Article
- Article
- Hantavirus entry: Perspectives and recent advances.Advances in virus research · 2019Article
- Crystal Structure of Glycoprotein C from a Hantavirus in the Post-fusion Conformation.PLoS pathogens · 2016Article
- Hantavirus Gn and Gc envelope glycoproteins: key structural units for virus cell entry and virus assembly.Viruses · 2014Review
- The major cellular sterol regulatory pathway is required for Andes virus infection.PLoS pathogens · 2014Article
- IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.Journal of virology · 2013Article
- Acid-activated structural reorganization of the Rift Valley fever virus Gc fusion protein.Journal of virology · 2012Article
- Surface display of rice stripe virus NSvc2 and analysis of its membrane fusion activity.Virologica Sinica · 2012Article
- Production and characterization of a recombinant single-chain antibody against Hantaan virus envelop glycoprotein.Applied microbiology and biotechnology · 2010Article
- Interactions and oligomerization of hantavirus glycoproteins.Journal of virology · 2010Article
- Functional analysis of the Bunyamwera orthobunyavirus Gc glycoprotein.The Journal of general virology · 2009Article
- Role of the cytoplasmic tail domains of Bunyamwera orthobunyavirus glycoproteins Gn and Gc in virus assembly and morphogenesis.Journal of virology · 2007Article
- Rab 5 is required for the cellular entry of dengue and West Nile viruses.Journal of virology · 2007Article
- Development of serological assays for Thottapalayam virus, an insectivore-borne Hantavirus.Clinical and vaccine immunology : CVI · 2007Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Hantaan virus (HTNV)-infected Vero E6 cells undergo cell fusion with both infected and uninfected cells under low-pH conditions. Flow cytometry and fluorescence microscopy of HTNV-infected Vero E6 cells showed that envelope glycoproteins (GPs) were located both on the cell surface and in the cytoplasm. Neutralizing monoclonal antibodies (MAbs) against the G1 and G2 envelope GPs inhibited cell fusion, whereas nonneutralizing MAbs against G1 or G2 and MAbs against the nucleocapsid protein (NP) did not. Transfected Vero E6 cells that expressed GPs but not those that expressed NP fused and formed syncytia. These results indicate that HTNV GPs act as fusogens at the cell surface. No fusion activity was observed either in infected Vero cells that were passaged more than 150 times or in BHK-21 cells, although GPs appeared to localize to the cell surface. This variability in fusion induction suggests the involvement of host cell factors in the process of cell membrane fusion.
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Registered trials
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