ArticleJournal of virology2004
Genetic bottlenecks reduce population variation in an experimental RNA virus population.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
What it found
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Who cites it
91 citing papers in PubMed, 208 citations in OpenAlex.
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- Genetic diversity and dynamics of plum pox virus populations in the alternative host American plum.Archives of virology · 2026Article
- Population structure and genetic variation of cucumber mosaic virus isolates in Serbia: evidence for high diversity and the occurrence of natural recombinant and reassortant isolates.Frontiers in plant science · 2026Article
- Experimental evolution of the host range dynamics in two isolates of potato virus Y.Virus evolution · 2026Article
- Characterization of the Pepper Virome in Oklahoma Reveals Emerging RNA and DNA Viruses.Pathogens (Basel, Switzerland) · 2025Article
- A historical perspective on arboviruses of public health interest in Southern Africa.Pathogens and global health · 2024Review
- Natural Populations from theJournal of fungi (Basel, Switzerland) · 2022Article
- Ecological and evolutionary dynamics of multi-strain RNA viruses.Nature ecology & evolution · 2022Review
- Determinants of Virus Variation, Evolution, and Host Adaptation.Pathogens (Basel, Switzerland) · 2022Review
- Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain.bioRxiv : the preprint server for biology · 2022Article
- Standing Genetic Diversity and Transmission Bottleneck Size Drive Adaptation in Bacteriophage Qβ.International journal of molecular sciences · 2022Article
- A Systems Biology Approach for Hypothesizing the Effect of Genetic Variants on Neuroimaging Features in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Article
- Strategies for Assessing Arbovirus Genetic Variability in Vectors and/or Mammals.Pathogens (Basel, Switzerland) · 2020Review
- Ratcheting down the virulence of SARS-CoV-2 in the COVID-19 pandemic.Journal of medical virology · 2020Article
- Transmission modes affect the population structure of potato virus Y in potato.PLoS pathogens · 2020Article
- Estimating viral bottleneck sizes for FMDV transmission within and between hosts and implications for the rate of viral evolution.Interface focus · 2020Article
- Marine Oomycetes of the GenusFrontiers in microbiology · 2020Article
- Article
- Hepatitis C virus (HCV) genotype 1b displays higher genetic variability of hypervariable region 1 (HVR1) than genotype 3.Scientific reports · 2019Article
- Koala and Wombat Gammaherpesviruses Encode the First Known Viral NTPDase Homologs and Are Phylogenetically Divergent from All Known Gammaherpesviruses.Journal of virology · 2019Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic bottlenecks are stochastic events that limit genetic variation in a population and result in founding populations that can lead to genetic drift. Evidence of past genetic bottlenecks in numerous biological systems, from mammals to viruses, has been described. In this study, we used an artificial population of Cucumber mosaic virus consisting of 12 restriction enzyme marker-bearing mutants. This population was inoculated onto young leaves of tobacco plants and monitored throughout the course of systemic infection. We show here that the genetic variation in a defined population of an RNA virus is significantly, stochastically, and reproducibly reduced during the systemic infection process, providing clear evidence of a genetic bottleneck.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.