ArticleAmerican journal of physiology. Endocrinology and metabolism2005
Reducing plasma HIV RNA improves muscle amino acid metabolism.
Article in American journal of physiology. Endocrinology and metabolism, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Whole-body and muscle protein metabolism are not affected by acute deviations from habitual protein intake in older men: the Hormonal Regulators of Muscle and Metabolism in Aging (HORMA) Study.The American journal of clinical nutrition · 2011Trial
- Nutrient ingestion, protein intake, and sex, but not age, affect the albumin synthesis rate in humans.The Journal of nutrition · 2007Trial
- Hormonal regulators of muscle and metabolism in aging (HORMA): design and conduct of a complex, double masked multicenter trial.Clinical trials (London, England) · 2007Trial
- Functional and tissue enrichment analyses suggest that SARS-CoV-2 infection affects host metabolism and catabolism mediated by interference on host proteins.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Article
- A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects.Alzheimer's & dementia (New York, N. Y.) · 2016Article
- Long-term impact of HIV wasting on physical function.AIDS (London, England) · 2016Observational
- Maternal post-absorptive leucine kinetics during late pregnancy in US women with HIV taking antiretroviral therapy: a cross-sectional pilot study.Clinical nutrition ESPEN · 2015Article
- A combined chemometric and quantitative NMR analysis of HIV/AIDS serum discloses metabolic alterations associated with disease status.Molecular bioSystems · 2014Article
- Biomedical consequences of alcohol use disorders in the HIV-infected host.Current HIV research · 2014Review
- Age attenuates leucine oxidation after eccentric exercise.International journal of sports medicine · 2013Article
- Article
- Substrate metabolism during basal and hyperinsulinemic conditions in adolescents and young-adults with Barth syndrome.Journal of inherited metabolic disease · 2013Article
- Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats.AIDS research and therapy · 2011Article
- Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
- Evaluation of early biomarkers of muscle anabolic response to testosterone.Journal of cachexia, sarcopenia and muscle · 2011Article
- Skeletal and cardiac myopathy in HIV-1 transgenic rats.American journal of physiology. Endocrinology and metabolism · 2008Article
- Effect of HIV-1-related protein expression on cardiac and skeletal muscles from transgenic rats.AIDS research and therapy · 2008Article
- Alternative equations for whole-body protein synthesis and for fractional synthetic rates of proteins.Metabolism: clinical and experimental · 2007Article
- Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates.Journal of the American Society for Mass Spectrometry · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We reported (Yarasheski KE, Zachwieja JJ, Gischler J, Crowley J, Horgan MM, and Powderly WG. Am J Physiol Endocrinol Metab 275: E577-E583, 1998) that AIDS muscle wasting was associated with an inappropriately low rate of muscle protein synthesis and an elevated glutamine rate of appearance (Ra Gln). We hypothesized that high plasma HIV RNA caused dysregulation of muscle amino acid metabolism. We determined whether a reduction in HIV RNA (> or =1 log) increased muscle protein synthesis rate and reduced R(a) Gln and muscle proteasome activity in 10 men and 1 woman (22-57 yr, 60-108 kg, 17-33 kg muscle) with advanced HIV (CD4 = 0-311 cells/microl; HIV RNA = 10-375 x 10(3) copies/ml). We utilized stable isotope tracer methodologies ([13C]Leu and [15N]Gln) to measure the fractional rate of mixed muscle protein synthesis and plasma Ra Gln in these subjects before and 4 mo after initiating their first or a salvage antiretroviral therapy regimen. After treatment, median CD4 increased (98 vs. 139 cells/microl, P = 0.009) and median HIV RNA was reduced (155,828 vs. 100 copies/ml, P = 0.003). Mixed muscle protein synthesis rate increased (0.062 +/- 0.005 vs. 0.078 +/- 0.006%/h, P = 0.01), Ra Gln decreased (387 +/- 33 vs. 323 +/- 15 micromol.kg fat-free mass(-1).h(-1), P = 0.04), and muscle proteasome chymotrypsin-like catalytic activity was reduced 14% (P = 0.03). Muscle mass was only modestly increased (1 kg, P = not significant). We estimated that, for each 10,000 copies/ml reduction in HIV RNA, approximately 3 g of additional muscle protein are synthesized per day. These findings suggest that reducing HIV RNA increases muscle protein synthesis and reduces muscle proteolysis, but muscle protein synthesis relative to whole body protein synthesis rate is not restored to normal, so muscle mass is not substantially increased.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.