ReviewDrug safety2004
The general practice research database: role in pharmacovigilance.
Review in Drug safety, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed.
- Performance of the Self-Controlled Case Series With Active Comparators for Drug Safety Signal Detection Using the Clinical Practice Research Datalink (CPRD).Pharmacoepidemiology and drug safety · 2025Article
- Data Resource Profile Update: CPRD GOLD.International journal of epidemiology · 2025Article
- The legacy effect of early HbA1c control on microvascular complications and hospital admissions in type 2 diabetes: findings from a large UK study.Therapeutic advances in endocrinology and metabolism · 2025Article
- Proton Pump Inhibitor Use and Risk of Developing Alzheimer's Disease or Vascular Dementia: A Case-Control Analysis.Drug safety · 2018Article
- Article
- Treatment choice, medication adherence and glycemic efficacy in people with type 2 diabetes: a UK clinical practice database study.BMJ open diabetes research & care · 2018Article
- A comparison of methods for estimating the temporal change in a continuous variable: Example of HbA1c in patients with diabetes.Pharmacoepidemiology and drug safety · 2017Article
- Trends in the prescription of novel oral anticoagulants in UK primary care.British journal of clinical pharmacology · 2017Article
- Association of Hypoglycemia With Subsequent Dementia in Older Patients With Type 2 Diabetes Mellitus.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Managing glycaemia in older people with type 2 diabetes: A retrospective, primary care-based cohort study, with economic assessment of patient outcomes.Diabetes, obesity & metabolism · 2017 · on this mapObservational
- The Risk of Achilles or Biceps Tendon Rupture in New Statin Users: A Propensity Score-Matched Sequential Cohort Study.Drug safety · 2016Article
- Latest trends in ADHD drug prescribing patterns in children in the UK: prevalence, incidence and persistence.BMJ open · 2016Article
- Asthma medication prescribing before, during and after pregnancy: a study in seven European regions.BMJ open · 2016Article
- Doubling of serum creatinine and the risk of cardiovascular outcomes in patients with chronic kidney disease and type 2 diabetes mellitus: a cohort study.Clinical epidemiology · 2016Article
- Prescribing of Antidiabetic Medicines before, during and after Pregnancy: A Study in Seven European Regions.PloS one · 2016Article
- Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2016Article
- No evidence for a decreased risk of thyroid cancer in association with use of metformin or other antidiabetic drugs: a case-control study.BMC cancer · 2015Article
- Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations.Scientific reports · 2015Article
- Benzodiazepine Use and Risk of Developing Alzheimer's Disease or Vascular Dementia: A Case-Control Analysis.Drug safety · 2015Article
- Antiepileptic drugs and the risk of ischaemic stroke and myocardial infarction: a population-based cohort study.BMJ open · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The General Practice Research Database (GPRD) is the world's largest computerised database of anonymised longitudinal clinical records from primary care. The database already has an international reputation in the field of drug safety signal evaluation where the results of GPRD-based pharmacoepidemiological studies have been used to inform regulatory pharmacovigilance decision making. The characteristics and richness of the data are such that the GPRD is likely to prove a key data resource for the proactive pharmacovigilance anticipated in risk management and pharmacovigilance plans. An update of recent developments to the database and new data available from it -- including spontaneously recorded suspected adverse drug reactions -- is presented in the article, with a description of how the data can be used to support a variety of pharmacovigilance applications. The possibility of using the GPRD in signal detection and assessment of the impact of pharmacovigilance activities in the future is also discussed.
Indexed as
Identifiers
15366975What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.