ArticleMammalian genome : official journal of the International Mammalian Genome Society2004
Polar overdominant inheritance of a DLK1 polymorphism is associated with growth and fatness in pigs.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Polar Overdominance Inheritance ofInternational journal of molecular sciences · 2026Article
- Functional Identification of PorcineAnimals : an open access journal from MDPI · 2022Article
- Fennel (Heliyon · 2021Article
- Review: Balancing Selection for Deleterious Alleles in Livestock.Frontiers in genetics · 2021Review
- A Transcriptome Analysis Reveals that Hepatic Glycolysis and Lipid Synthesis Are Negatively Associated with Feed Efficiency in DLY Pigs.Scientific reports · 2020Article
- Analysis of the Bovine DLK1 Gene Polymorphism and Its Relation to Lipid Metabolism in Chinese Simmental.Animals : an open access journal from MDPI · 2020Article
- Genomic diversity, linkage disequilibrium and selection signatures in European local pig breeds assessed with a high density SNP chip.Scientific reports · 2019Article
- Balanced selection on purebred and crossbred performance increases gain in crossbreds.Genetics, selection, evolution : GSE · 2018Article
- Expressed alleles of imprinted IGF2, DLK1 and MEG3 colocalize in 3D-preserved nuclei of porcine fetal cells.BMC cell biology · 2016Article
- Parallel Selection Revealed by Population Sequencing in Chicken.Genome biology and evolution · 2015Article
- Genomic imprinting effects on complex traits in domesticated animal species.Frontiers in genetics · 2015Review
- A whole genomic scan to detect selection signatures between Berkshire and Korean native pig breeds.Journal of animal science and technology · 2014Article
- A least squares regression model to detect quantitative trait Loci with polar overdominance in a cross of outbred breeds: simulation.Asian-Australasian journal of animal sciences · 2013Article
- FA1 Induces Pro-Inflammatory and Anti-Adipogenic Pathways/Markers in Human Myotubes Established from Lean, Obese, and Type 2 Diabetic Subjects but Not Insulin Resistance.Frontiers in endocrinology · 2013Article
- Maternal and paternal genomes differentially affect myofibre characteristics and muscle weights of bovine fetuses at midgestation.PloS one · 2013Article
- Genes contributing to genetic variation of muscling in sheep.Frontiers in genetics · 2012Article
- Article
- Polymorphism of DLK1 and CLPG gene and their association with phenotypic traits in Chinese cattle.Molecular biology reports · 2011Article
- DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle.BMC genetics · 2010Article
- Expression of DLK1 and MEG3 genes in porcine tissues during postnatal development.Genetics and molecular biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The polar overdominance model of inheritance was proposed to explain the non-Mendelian expression of callipyge muscular hypertrophy in sheep. The callipyge locus (CLPG) maps to the distal portion of ovine Chromosome 18 within the DLK1- GTL2 region and corresponds to human Chromosome 14q32, where uniparental disomy (UPD) of the region is associated with multiple congenital anomalies, including growth retardation and obesity. We investigated the porcine DLK1- GTL2 region in a cross of two pig breeds to determine if the callipyge polar overdominance is present in another species. Analyses of the parental origin of DLK1 polymorphism in the F2 offspring found that paternal inheritance of DLK1 allele 2 and maternal inheritance of the allele 1 was significantly associated with decreased fat deposition and increased lean muscle mass, while the opposite parental inheritance of these alleles was associated with slower prenatal and postnatal growth. These results suggest that the polar overdominance mode of inheritance is present in the pig chromosomal region that is homologous to the CLPG locus in sheep. Further study in pigs can provide important insights into understanding the molecular regulation of imprinted genes that are associated with human UPD14 and sheep callipyge phenotypes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.