ArticleDiabetologia2004
Biological correlates of day-to-day variation in flow-mediated dilation in individuals with Type 2 diabetes: a study of test-retest reliability.
Article in Diabetologia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Effect of Incorporating 1 Avocado per Day Versus Habitual Diet on Vascular Function in Adults With Abdominal Obesity: An Ancillary Study of HAT, a Randomized Controlled Trial.Journal of the American Heart Association · 2024Trial
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- Time-Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above-Normal Blood Pressure.Journal of the American Heart Association · 2021Trial
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- Diets containing pistachios reduce systolic blood pressure and peripheral vascular responses to stress in adults with dyslipidemia.Hypertension (Dallas, Tex. : 1979) · 2012Trial
- Test-retest reliability of pulse amplitude tonometry measures of vascular endothelial function: implications for clinical trial design.Vascular medicine (London, England) · 2012Trial
- Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia.The American journal of clinical nutrition · 2011Trial
- Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function.Journal of the American College of Nutrition · 2010Trial
- Flow mediated dilation of the brachial artery: an investigation of methods requiring further standardization.BMC cardiovascular disorders · 2007Trial
- Brachial artery flow-mediated dilation is less repeatable in children with a chronic inflammatory disease compared to their healthy peers.Clinical physiology and functional imaging · 2026Article
- Reliability of popliteal artery flow-mediated dilation in the seated position.Physiological reports · 2025Article
- Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2022Article
- A novel operator-independent noninvasive device for assessing arterial reactivity.International journal of cardiology. Heart & vasculature · 2022Article
- Physical Fitness and Cardiovascular Risk Factors in Novel Diabetes Subgroups.The Journal of clinical endocrinology and metabolism · 2022Article
- Elevated serum thyrotropin levels and endothelial dysfunction in a prospective hemodialysis cohort.Hemodialysis international. International Symposium on Home Hemodialysis · 2022Article
- Vascular function in continuous-flow left ventricular assist device recipients: effect of a single pulsatility treatment session.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- A methodological approach to non-invasive assessments of vascular function and morphology.Journal of visualized experiments : JoVE · 2015Article
- Test-retest reliability of peripheral arterial tonometry in the metabolic syndrome.Diabetes & vascular disease research · 2014Article
- Reliability of ultrasonography in detecting flow mediated dilation.The international journal of cardiovascular imaging · 2009Article
- Can the measurement of brachial artery flow-mediated dilation be applied to the acute exercise model?Cardiovascular ultrasound · 2007Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
aims/hypothesisDysfunction of the vascular endothelium is commonly observed in Type 2 diabetes, and endothelial function may be an important outcome for clinical trials in diabetic samples. However, the most commonly used non-invasive test of endothelial function (flow-mediated dilation [FMD]) is technically challenging to perform, and no previous studies have carefully examined the reproducibility of FMD measurements in individuals with Type 2 diabetes. In this study, we tested the hypothesis that larger day-to-day changes in insulin and glucose are associated with larger fluctuations in FMD.
methodsUltrasound was used to measure the FMD (% change from baseline diameter) of the brachial artery in 18 healthy adults with Type 2 diabetes on three separate occasions, in the absence of changes to diet, activity level or medications. The CV and mean deviations between pairs of FMD scores in the same individual were used as the primary outcome variables.
resultsThe CV for FMD (29.7%) was higher than the level traditionally accepted for biochemical assays. However, this CV estimate is within the low range of published values for FMD in healthy individuals. FMD scores were not significantly correlated with glucose or insulin levels. However, subjects with the largest variability in FMD also showed the largest fluctuations in glucose ( r=0.52), insulin ( r=0.47) and heart rate ( r=0.48) ( p</=0.05). CONCLUSIONS/
interpretationFMD can be reliably measured in individuals with Type 2 diabetes, and population-specific data on reliability is critical for the design of adequately powered studies of endothelial function.
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