ArticleProceedings of the National Academy of Sciences of the United States of America2004
Iron-oxo clusters biomineralizing on protein surfaces: structural analysis of Halobacterium salinarum DpsA in its low- and high-iron states.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 124 citations in OpenAlex.
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- The Mechanism of Mineral Nucleation and Growth in a Mini-Ferritin.Journal of the American Chemical Society · 2025Article
- Investigation of the global translational response to oxidative stress in the model archaeonmSphere · 2025Article
- Iron is an important influence of volcanic ash input on the evolution of deep-sea ecosystems.Microbiology spectrum · 2025Article
- Comparative analysis of DNA binding and abiotic stress tolerance of Dps All4145 and its homologs in Anabaena PCC 7120.Molecular biology reports · 2025Article
- HaloClass: Salt-Tolerant Protein Classification with Protein Language Models.The protein journal · 2024Article
- Multifunctional biomolecular corona-inspired nanoremediation of antibiotic residues.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- TroR is the primary regulator of the iron homeostasis transcription network in the halophilic archaeon Haloferax volcanii.Nucleic acids research · 2024Article
- Bacterioferritin nanocage structures uncover the biomineralization process in ferritins.PNAS nexus · 2023Article
- Structural Insights into Iron Ions Accumulation in Dps Nanocage.International journal of molecular sciences · 2022Article
- An Overview of Dps: Dual Acting Nanovehicles in Prokaryotes with DNA Binding and Ferroxidation Properties.Sub-cellular biochemistry · 2021Review
- Bacterial iron detoxification at the molecular level.The Journal of biological chemistry · 2020Review
- Biochemical and structural characterization of a thermostable Dps protein with His-type ferroxidase centers and outer metal-binding sites.FEBS open bio · 2020Article
- How to Cope With Heavy Metal Ions: Cellular and Proteome-Level Stress Response to Divalent Copper and Nickel inFrontiers in microbiology · 2019Article
- Article
- Multiplex quantitative SILAC for analysis of archaeal proteomes: a case study of oxidative stress responses.Environmental microbiology · 2018Article
- The Oligomeric Form of the Escherichia coli Dps Protein Depends on the Availability of Iron Ions.Molecules (Basel, Switzerland) · 2017Article
- Observation of gold sub-nanocluster nucleation within a crystalline protein cage.Nature communications · 2017Article
- Unique features of a Japanese 'Candidatus Liberibacter asiaticus' strain revealed by whole genome sequencing.PloS one · 2014Article
- An experimental point of view on hydration/solvation in halophilic proteins.Frontiers in microbiology · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The crystal structure of the Dps-like (Dps, DNA-protecting protein during starvation) ferritin protein DpsA from the halophile Halobacterium salinarum was determined with low endogenous iron content at 1.6-A resolution. The mechanism of iron uptake and storage was analyzed in this noncanonical ferritin by three high-resolution structures at successively increasing iron contents. In the high-iron state of the DpsA protein, up to 110 iron atoms were localized in the dodecameric protein complex. For ultimate iron storage, the archaeal ferritin shell comprises iron-binding sites for iron translocation, oxidation, and nucleation. Initial iron-protein interactions occur through acidic residues exposed along the outer surface in proximity to the iron entry pore. This narrow pore permits translocation of ions toward the ferroxidase centers via two discrete steps. Iron oxidation proceeds by transient formation of tri-iron ferroxidase centers. Iron storage by biomineralization inside the ferritin shell occurs at two iron nucleation centers. Here, a single iron atom provides a structural seed for iron-oxide cluster formation. The clusters with up to five iron atoms adopt a geometry that is different from natural biominerals like magnetite but resembles iron clusters so far known only from bioinorganic model compounds.
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