ArticleProceedings of the National Academy of Sciences of the United States of America2004
Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- AP-1B Controls Several Levels of Cell Proliferation and Differentiation in Mouse Enteroids.Biology of the cell · 2026Article
- MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.Endocrinology · 2022Article
- Induction of apically mistrafficked epiregulin disrupts epithelial polarity via aberrant EGFR signaling.Journal of cell science · 2021Article
- The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80.Molecular biology of the cell · 2021Article
- Role of Polarity Proteins in the Generation and Organization of Apical Surface Protrusions.Cold Spring Harbor perspectives in biology · 2018Review
- Epithelial Morphogenesis during Liver Development.Cold Spring Harbor perspectives in biology · 2017Review
- Rab11-FIP1 phosphorylation by MARK2 regulates polarity in MDCK cells.Cellular logistics · 2017Article
- The unique polarity phenotype of hepatocytes.Experimental cell research · 2014Review
- Effects of T208E activating mutation on MARK2 protein structure and dynamics: Modeling and simulation.Molecular biology research communications · 2014Article
- Build them up and break them down: Tight junctions of cell lines expressing typical hepatocyte polarity with a varied repertoire of claudins.Tissue barriers · 2013Article
- Hepatocyte polarity.Comprehensive Physiology · 2013Review
- Role of membrane traffic in the generation of epithelial cell asymmetry.Nature cell biology · 2012Review
- Polarization and myelination in myelinating glia.ISRN neurology · 2012Article
- Molecular regulation of lumen morphogenesis.Current biology : CB · 2011Review
- Apical trafficking in epithelial cells: signals, clusters and motors.Journal of cell science · 2009Review
- Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity.Cold Spring Harbor perspectives in biology · 2009Review
- Coordinated protein sorting, targeting and distribution in polarized cells.Nature reviews. Molecular cell biology · 2008Review
- LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster.The Journal of cell biology · 2008Article
- Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs.Nature immunology · 2008Article
- Polarity-regulating kinase partitioning-defective 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Simple (i.e., nonstratified) epithelial cells use two different routes to target their newly synthesized luminal plasma membrane proteins to the cell surface: a direct route from the Golgi complex, as in the kidney-derived MDCK cell line, or an indirect route that involves a intermediate stop at the ab-luminal (basolateral) membrane, as in hepatocytes. The mechanisms or proteins responsible for these different protein targeting strategies are not known. Here, we show that increased expression of EMK1, a mammalian ortholog of Caenorhabditis elegans Par-1, in MDCK cells promotes a switch from a direct to a transcytotic mode of apical protein delivery and other trafficking changes typical of hepatocytes. These results, together with our recent demonstration that PAR-1 promotes morphological features of hepatocytes in MDCK cells, indicate that Par-1 modulates the developmental decision to build a columnar versus a hepatic epithelial cell. To our knowledge, Par-1 is the first gene assigned to this task in epithelial morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.