ArticleJournal of clinical microbiology2004
Use of the minimum spanning tree model for molecular epidemiological investigation of a nosocomial outbreak of hepatitis C virus infection.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- A healthcare-associated outbreak of hepatitis C virus infections attributable to tampering injectable anaesthetic opioids, South Germany, 2017-2018.Frontiers in public health · 2025Article
- Evaluating the potential of whole-genome sequencing for tracing transmission routes in experimental infections and natural outbreaks of bovine respiratory syncytial virus.Veterinary research · 2022Article
- Genome Evolution of Invasive Methicillin-Resistant Staphylococcus aureus in the Americas.Microbiology spectrum · 2022Article
- A knowledge graph-based method for epidemic contact tracing in public transportation.Transportation research. Part C, Emerging technologies · 2022Article
- Identification of a canine coronavirus in Australian racing Greyhounds.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Phylogenomics reveals multiple introductions and early spread of SARS-CoV-2 into Peru.Journal of medical virology · 2021Article
- Bayesian reconstruction of transmission trees from genetic sequences and uncertain infection times.Statistical applications in genetics and molecular biology · 2020Article
- Article
- Probabilistic reconstruction of measles transmission clusters from routinely collected surveillance data.Journal of the Royal Society, Interface · 2020Article
- Genotyping SARS-CoV-2 through an interactive web application.The Lancet. Digital health · 2020Article
- Genomic polymorphism of Trifolium repens root nodule symbionts from heavy metal-abundant 100-year-old waste heap in southern Poland.Archives of microbiology · 2019Article
- Bayesian inference of transmission chains using timing of symptoms, pathogen genomes and contact data.PLoS computational biology · 2019Article
- Degree and centrality-based approaches in network-based variable selection: Insights from the Singapore Longitudinal Aging Study.PloS one · 2019Article
- Distribution and characterization of Shiga toxin converting temperate phages carried by Shigella flexneri in Hispaniola.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Article
- When are pathogen genome sequences informative of transmission events?PLoS pathogens · 2018Article
- Shared Genomic Variants: Identification of Transmission Routes Using Pathogen Deep-Sequence Data.American journal of epidemiology · 2017Article
- Integrating molecular epidemiology and social network analysis to study infectious diseases: Towards a socio-molecular era for public health.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Review
- Using genomics data to reconstruct transmission trees during disease outbreaks.Revue scientifique et technique (International Office of Epizootics) · 2016Article
- Molecular Infectious Disease Epidemiology: Survival Analysis and Algorithms Linking Phylogenies to Transmission Trees.PLoS computational biology · 2016Article
- Accurate Genetic Detection of Hepatitis C Virus Transmissions in Outbreak Settings.The Journal of infectious diseases · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The minimum spanning tree (MST) model was applied to identify the history of transmission of hepatitis C virus (HCV) infection in an outbreak involving five children attending a pediatric oncology-hematology outpatient ward between 1992 and 2000. We collected blood samples from all children attending since 1992, all household contacts, and one health care worker positive for antibody to HCV (anti-HCV). HCV RNA detection was performed with these samples and with smears of routinely collected bone marrow samples. For all isolates, we performed sequence analysis and phylogenetic tree analysis of hypervariable region 1 of the E2 gene. The MST model was applied to clinical-epidemiological and molecular data. No additional cases were detected. All children, but not the health care worker, showed genotype 3a. On six occasions, all but one child had shared the medication room with another patient who later seroconverted. HCV RNA detection in bone marrow smears revealed, in some cases, a delay of several months in anti-HCV responses. Sequence analysis and phylogenetic tree analysis revealed a high identity among the isolates. The MST model applied to molecular data, together with the clinical-epidemiological data, allowed us to identify the source of the outbreak and the most probable patient-to-patient chain of transmission. The management of central venous catheters was suspected to be the probable route of transmission. In conclusion, the MST model, supported by an exhaustive clinical-epidemiological investigation, appears to be a useful tool in tracing the history of transmission in outbreaks of HCV infection.
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