ArticleJournal of clinical microbiology2004
Microevolution of Candida albicans strains during catheter-related candidemia.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Candida auris Clinical Isolates from South Korea: Identification, Antifungal Susceptibility, and Genotyping.Journal of clinical microbiology · 2019Article
- Association Between Candiduria and Candidemia: A Clinical and Molecular Analysis of Cases.Mycopathologia · 2017Article
- Genotyping and Persistence of Candida albicans from Pregnant Women with Vulvovaginal Candidiasis.Mycopathologia · 2017Article
- The Correlation Between Candida Colonization of Distinct Body Sites and Invasive Candidiasis in Emergency Intensive Care Units: Statistical and Molecular Biological Analysis.Mycopathologia · 2016Article
- Candida albicans Carriage in Children with Severe Early Childhood Caries (S-ECC) and Maternal Relatedness.PloS one · 2016Article
- The Unspecific Side of Acquired Immunity Against Infectious Disease: Causes and Consequences.Frontiers in microbiology · 2015Review
- Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant.PLoS genetics · 2014Article
- Analysis of strain relatedness using high resolution melting in a case of recurrent candiduria.BMC microbiology · 2013Article
- Article
- MALDI-TOF mass spectrometry and microsatellite markers to evaluate Candida parapsilosis transmission in neonatal intensive care units.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Investigation of a cluster of Candida albicans invasive Candidiasis in a neonatal intensive care unit by pulsed-field gel electrophoresis.TheScientificWorldJournal · 2012Article
- Genetic diversity among Korean Candida albicans bloodstream isolates: assessment by multilocus sequence typing and restriction endonuclease analysis of genomic DNA by use of BssHII.Journal of clinical microbiology · 2011Article
- Multilocus sequence typing for Candida albicans isolates from candidemic patients: comparison with Southern blot hybridization and pulsed-field gel electrophoresis analysis.The Korean journal of laboratory medicine · 2011Article
- Genetic relationships between Candida albicans strains isolated from dental plaque, trachea, and bronchoalveolar lavage fluid from mechanically ventilated intensive care unit patients.Journal of oral microbiology · 2011Article
- Candida albicans: genotyping methods and clade related phenotypic characteristics.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2010Article
- Virulence attenuation of Candida albicans genetic variants isolated from a patient with a recurrent bloodstream infection.PloS one · 2010Article
- Correlation between Etest, disk diffusion, and microdilution methods for antifungal susceptibility testing of Candida species from infection and colonization.Journal of clinical laboratory analysis · 2009Article
- Changes in karyotype and azole susceptibility of sequential bloodstream isolates from patients with Candida glabrata candidemia.Journal of clinical microbiology · 2007Article
- Kodamaea ohmeri isolates from patients in a university hospital: identification, antifungal susceptibility, and pulsed-field gel electrophoresis analysis.Journal of clinical microbiology · 2007Article
- Biofilm formation in clinical Candida isolates and its association with virulence.Microbes and infectionArticle
Corrections and comments
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10 authors.
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Abstract
We examined microevolution in a series of Candida albicans strains isolated from patients with catheter-related candidemia. Sixty-one isolates (29 from blood, 18 from catheters, 10 from urine, and 4 from other sites) were obtained from 15 patients who were admitted to the same hospital over a 3-year period. Isolates were analyzed by using Southern hybridization with the C1 fragment of Ca3 as a probe (C1 fingerprinting) and pulsed-field gel electrophoresis (PFGE). PFGE typing consisted of electrophoretic karyotyping (EK) and restriction endonuclease analysis of genomic DNA (REAG) by using SfiI (REAG-S) and BssHII (REAG-B). When catheter isolates were compared with blood isolates from the same patient, catheter isolates from 5 of 14 patients (36%) exhibited minor band differences (microevolution) relative to blood isolates in either C1 fingerprinting (n = 4), REAG-S (n = 3), or REAG-B (n = 5) profiles, although they had identical EK patterns. However, the other sequential isolates from each patient, which had identical EK patterns, showed the same REAG and C1 fingerprinting patterns. Both fingerprinting methods revealed that two distinct genotypes were shared by isolates from seven patients in a neonatal intensive care unit, suggesting two nosocomial clusters. Except for two catheter isolates from the index patients of each cluster, no consecutive isolates collected from each of the two clusters showed any microevolution during the 2- or 7-month cluster periods. The findings suggest that in catheter-related candidemia, some C. albicans strains undergo microevolution during catheter colonization.
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