ArticleGenome research2004
Organization and evolution of a gene-rich region of the mouse genome: a 12.7-Mb region deleted in the Del(13)Svea36H mouse.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The Influence of the Prolactins on the Development of the Uterus in Neonatal Mice.Frontiers in veterinary science · 2022Article
- Article
- Hypoxia and Placental Development.Birth defects research · 2017Review
- Contrasted evolution of the vomeronasal receptor repertoires in mammals and squamate reptiles.Genome biology and evolution · 2013Article
- Bridging sequence diversity and tissue-specific expression by DNA methylation in genes of the mouse prolactin superfamily.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Model organisms inform the search for the genes and developmental pathology underlying malformations of the human hindbrain.Seminars in pediatric neurology · 2009Review
- Spatial and temporal expression of the 23 murine Prolactin/Placental Lactogen-related genes is not associated with their position in the locus.BMC genomics · 2008Article
- Decidual cells produce a heparin-binding prolactin family cytokine with putative intrauterine regulatory actions.The Journal of biological chemistry · 2008Article
- Cryptic speciation in a model invertebrate chordate.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- A standardized nomenclature for the mouse and rat prolactin superfamilies.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- The rat prolactin gene family locus: species-specific gene family expansion.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Genomic anatomy of the Tyrp1 (brown) deletion complex.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Dissecting the genetic complexity of human 6p deletion syndromes by using a region-specific, phenotype-driven mouse screen.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The Vertebrate Genome Annotation (Vega) database.Nucleic acids research · 2005Article
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Authors and funding
19 authors.
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Abstract
Del(13)Svea36H (Del36H) is a deletion of approximately 20% of mouse chromosome 13 showing conserved synteny with human chromosome 6p22.1-6p22.3/6p25. The human region is lost in some deletion syndromes and is the site of several disease loci. Heterozygous Del36H mice show numerous phenotypes and may model aspects of human genetic disease. We describe 12.7 Mb of finished, annotated sequence from Del36H. Del36H has a higher gene density than the draft mouse genome, reflecting high local densities of three gene families (vomeronasal receptors, serpins, and prolactins) which are greatly expanded relative to human. Transposable elements are concentrated near these gene families. We therefore suggest that their neighborhoods are gene factories, regions of frequent recombination in which gene duplication is more frequent. The gene families show different proportions of pseudogenes, likely reflecting different strengths of purifying selection and/or gene conversion. They are also associated with relatively low simple sequence concentrations, which vary across the region with a periodicity of approximately 5 Mb. Del36H contains numerous evolutionarily conserved regions (ECRs). Many lie in noncoding regions, are detectable in species as distant as Ciona intestinalis, and therefore are candidate regulatory sequences. This analysis will facilitate functional genomic analysis of Del36H and provides insights into mouse genome evolution.
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