SynthesisBMJ (Clinical research ed.)2004
Interventions for basal cell carcinoma of the skin: systematic review.
Synthesis in BMJ (Clinical research ed.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.
- Interventions for preventing non-melanoma skin cancers in high-risk groups.The Cochrane database of systematic reviews · 2007Pooled it
- [Surgical techniques in the treatment of basal cell carcinoma-a prospective investigation].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2020Trial
- Intraoral Basal Cell Carcinoma of Soft Palate: A Diagnostic Dilemma and Review of Literature.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Early clinical experience with a degraded 4 MeV electron beam in radiotherapy of superficial basal cell carcinoma.Physics and imaging in radiation oncology · 2023Article
- Basal Cell Carcinoma: A Narrative Review on Contemporary Diagnosis and Management.Oncology and therapy · 2022Review
- Review
- Metastatic basal cell carcinoma of buccal mucosa: a report of a rare case.World journal of surgical oncology · 2022Article
- Assessment of Basal Cell Carcinoma Using Dermoscopy and High Frequency Ultrasound Examination.Diagnostics (Basel, Switzerland) · 2022Review
- Integrated care pathways and the hub-and-spoke model for the management of non-melanoma skin cancer: A proposal of the Italian Association of Hospital Dermatologists (ADOI).Dermatology reports · 2021Article
- Computed tomography-based flap brachytherapy for non-melanoma skin cancers of the face.Journal of contemporary brachytherapy · 2021Article
- Basal Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches.Biomedicines · 2020Review
- Surgical Margin of Excision in Basal Cell Carcinoma: A Systematic Review of Literature.Cureus · 2020Review
- A dosimetric study of electron beam therapy vs. high-dose-rate mould brachytherapy in adjuvant treatment of non-melanoma skin carcinomas of the head and neck region.Journal of contemporary brachytherapy · 2019Article
- Nonsurgical Options for the Treatment of Basal Cell Carcinoma.Dermatology practical & conceptual · 2019Article
- Imiquimod 5% cream for the treatment of large nodular basal cell carcinoma at the medial canthal area.Indian journal of ophthalmology · 2017Article
- Highly conformal CT based surface mould brachytherapy for non-melanoma skin cancers of earlobe and nose.Journal of contemporary brachytherapy · 2016Article
- Traditional versus streamlined management of basal cell carcinoma (BCC): A cost analysis.Journal of the American Academy of Dermatology · 2015Article
- The dermatoscopic universe of basal cell carcinoma.Dermatology practical & conceptual · 2014Review
- Predictors of recurrence after radiotherapy for non-melanoma skin cancer.Current oncology (Toronto, Ont.) · 2014Article
- Characteristics of Mixed Type Basal Cell Carcinoma in Comparison to Other BCC Subtypes.Indian journal of dermatology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the effects of treatments for basal cell carcinoma.
methodsSystematic review of randomised controlled trials.
main outcome measureRecurrence of basal cell carcinoma at three years or beyond, assessed clinically. STUDIES REVIEWED: Randomised controlled trials of interventions for histologically confirmed basal cell carcinoma (published and unpublished material; no language restrictions).
results25 studies were identified, covering seven therapeutic categories. Only one study of surgical excision versus radiotherapy contained primary outcome data, which showed significantly more persistent tumours and recurrences in the radiotherapy group compared with surgery (odds ratio 0.09, 95% confidence interval 0.01 to 0.67). One study compared cryotherapy with surgery, with inconclusive results at one year. In a comparison of radiotherapy with cryotherapy, significantly more recurrences occurred at one year in the cryotherapy group. Preliminary studies suggest a short term success rate of 87-88% for imiquimod cream in the treatment of superficial basal cell carcinoma, although this cream has not been compared with surgery. No consistent evidence was found for the other treatment modalities.
conclusionsLittle good quality research has been done on the treatments used for the most common cancer in humans. Most trials have included only people with basal cell carcinoma occurring at low risk sites. Only one trial measured recurrence at four years; recurrence rates at one year should be interpreted with caution. Surgery and radiotherapy seem to be the most effective treatments; surgery showed the lowest failure rates. Other treatments might have some use but need to be compared with surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.