ArticleOncogene2004
Involvement of p53 and Fas/CD95 in murine neural progenitor cell response to ionizing irradiation.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Emerging role of radiopharmaceutical therapy in oncology: advances, challenges, and future directions.JNCI cancer spectrum · 2026Review
- Cell death in glioblastoma and the central nervous system.Cellular oncology (Dordrecht, Netherlands) · 2025Review
- Article
- DNA Damage by Radiopharmaceuticals and Mechanisms of Cellular Repair.Pharmaceutics · 2023Review
- Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors.Nucleic acids research · 2017Article
- Current Evidence for Developmental, Structural, and Functional Brain Defects following Prenatal Radiation Exposure.Neural plasticity · 2016Review
- A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis.Journal of neurodevelopmental disorders · 2015Article
- Assessing cell cycle progression of neural stem and progenitor cells in the mouse developing brain after genotoxic stress.Journal of visualized experiments : JoVE · 2014Article
- Lack of a p21waf1/cip -dependent G1/S checkpoint in neural stem and progenitor cells after DNA damage in vivo.Stem cells (Dayton, Ohio) · 2012Article
- CD95 is part of a let-7/p53/miR-34 regulatory network.PloS one · 2012Article
- p53 in stem cells.World journal of biological chemistry · 2011Article
- In vitro study on apoptosis induced by strontium-89 in human breast carcinoma cell line.Journal of biomedicine & biotechnology · 2011Article
- Fas activation increases neural progenitor cell survival.Journal of neuroscience research · 2010Article
- BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Moclobemide upregulated Bcl-2 expression and induced neural stem cell differentiation into serotoninergic neuron via extracellular-regulated kinase pathway.British journal of pharmacology · 2006Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the role of tumor suppressor p53 and Fas (CD95/APO-1), a member of the tumor necrosis factor receptor family, in neural progenitors response to gamma-irradiation exposure. Telencephalic cells were obtained from wild-type C57Bl/6, or p53-/- or fas-/-, 15-day-old mouse embryos. They were cultured in conditions allowing neural progenitors to form proliferating clusters (neurospheres). A 2 Gy gamma-irradiation induced a G1 cell cycle arrest and triggered apoptosis in wild-type neural progenitor cultures in correlation with an enhanced expression of p53 and of its downstream target p21(WAF1), both of them acquiring a nuclear localization. These effects did not occur in p53-/- neural progenitors demonstrating the central role played by p53 in their response to ionizing radiation. Furthermore, the monoclonal antibody Jo2 directed against Fas induced apoptosis of wild type but not of fas-/- neural progenitors, indicating the existence of a functional Fas signaling pathway in neural progenitors. Ionizing radiation induced an increase of Fas membrane expression related to a p53-dependent increase of fas mRNA expression in wild-type neural progenitors. Moreover, fas-/- neural progenitors exhibited delayed radiation-induced apoptosis compared to wild-type cells. Therefore, these findings establish a role for Fas/CD95 related to p53 in the response of neural progenitors to gamma-radiation exposure. Similar mechanisms could be triggered in neural progenitors in case of different stresses during brain development or in the course of various diseases affecting the adult brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.