ArticleOncogene2004
Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- It's Getting Complicated-A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy.Frontiers in cell and developmental biology · 2022Review
- Review
- How Cancer Exploits Ribosomal RNA Biogenesis: A Journey beyond the Boundaries of rRNA Transcription.Cells · 2019Review
- Dual Role of the Alternative Reading Frame ARF Protein in Cancer.Biomolecules · 2019Review
- Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.Nucleic acids research · 2018Article
- New roles for Dicer in the nucleolus and its relevance to cancer.Cell cycle (Georgetown, Tex.) · 2017Review
- ING1 regulates rRNA levels by altering nucleolar chromatin structure and mTOR localization.Nucleic acids research · 2017Article
- Insights into the regulation of neuronal viability by nucleophosmin/B23.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- The ARF tumor-suppressor controls Drosha translation to prevent Ras-driven transformation.Oncogene · 2014Article
- Article
- P19ARF and RasV¹² offer opposing regulation of DHX33 translation to dictate tumor cell fate.Molecular and cellular biology · 2013Article
- Protein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell lines.Biochemistry · 2011Article
- Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.The Journal of biological chemistry · 2010Article
- ARF stimulates XPC to trigger nucleotide excision repair by regulating the repressor complex of E2F4.EMBO reports · 2009Article
- A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function.Molecular and cellular biology · 2008Article
- Feedback regulation of c-Myc by ribosomal protein L11.Cell cycle (Georgetown, Tex.) · 2007Review
- Therapeutic targets in the ARF tumor suppressor pathway.Current medicinal chemistry · 2007Review
- Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylation.Oncogene · 2006Article
- DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer.Journal of molecular histology · 2006Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tumor suppressor Arf (Alternative Reading Frame) protein (p14ARF in human and p19ARF in mouse) is mainly located in the nucleolus consistent with its subcellular localization, the protein has been shown to specifically interact with 5.8S rRNA and with B23/Nucleophosmin and to regulate ribosome biogenesis. Here, we show that the p14ARF protein interacts with chromatin and is recovered by chromatin immunoprecipitation (ChIP) in a fraction that contains a DNA sequence of the rRNA gene promoter. In addition, topoisomerase I (Topo I) that has been shown to interact with p14ARF coprecipitates with p14ARF containing chromatin. These data, in view of the function for Topo I in rRNA transcription, are consistent with a role for the p14ARF-Topo I complex in rRNA transcription and/or maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.