ArticleGut2004
Enteropathy precedes type 1 diabetes in the BB rat.
Article in Gut, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 83 citations in OpenAlex.
- Prevalence and co-existence of cardiometabolic risk factors and associations with nutrition-related and socioeconomic indicators in a national sample of Gambian women.Scientific reports · 2021Trial
- IL-22, a vital cytokine in autoimmune diseases.Clinical and experimental immunology · 2024Review
- GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation.Acta pharmacologica Sinica · 2024Article
- Host-microbiota interactions shaping T-cell response and tolerance in type 1 diabetes.Frontiers in immunology · 2022Review
- Review
- Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Higher abundance of enterovirus A species in the gut of children with islet autoimmunity.Scientific reports · 2019Article
- Recent Advances on Microbiota Involvement in the Pathogenesis of Autoimmunity.International journal of molecular sciences · 2019Review
- Autoimmunity and intestinal colonization by Candida albicans in patients with type 1 diabetes at the time of the diagnosis.Korean journal of pediatrics · 2018Article
- Berberine Attenuates Intestinal Mucosal Barrier Dysfunction in Type 2 Diabetic Rats.Frontiers in pharmacology · 2017Article
- Epithelial Barrier Function in Gut-Bone Signaling.Advances in experimental medicine and biology · 2017Review
- Oral Probiotic VSL#3 Prevents Autoimmune Diabetes by Modulating Microbiota and Promoting Indoleamine 2,3-Dioxygenase-Enriched Tolerogenic Intestinal Environment.Journal of diabetes research · 2016Article
- The gut microbiota and Type 1 Diabetes.Clinical immunology (Orlando, Fla.) · 2015Review
- Type 1 diabetes and gut microbiota: Friend or foe?Pharmacological research · 2015Review
- Gut immune deficits in LEW.1AR1-iddm rats partially overcome by feeding a diabetes-protective diet.Immunology · 2015Article
- Effect of dietary gluten on dendritic cells and innate immune subsets in BALB/c and NOD mice.PloS one · 2015Article
- Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes.Diabetes · 2014Article
- Dietary gluten and the development of type 1 diabetes.Diabetologia · 2014Review
- From intestinal permeability to dysmotility: the biobreeding rat as a model for functional gastrointestinal disorders.PloS one · 2014Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThere is increasing evidence implicating intestinal immune responses to dietary proteins in the pathogenesis of type 1 autoimmune diabetes (T1D). Here we investigated the association between intestinal pathology and dietary factors in T1D by examining the mucosal architecture in the BB rat model.
methodsBB control (BBc) and diabetes prone (BBdp) rats were fed either a diabetes retardant hydrolysed casein based diet or one of two cereal based diets that promote the development of diabetes. Intestinal architecture was assessed in the jejunum by microdissection, histology, and immunohistology, and by measuring peroxidase activity and brush border invertase levels.
resultsEnteropathy was present in BBdp rats soon after weaning, as assessed by increases in crypt length and in the proliferative activity of crypt epithelial cells in the jejunum, and this remained constant until 120 days of age. There was also a decrease in invertase activity, as well as increased numbers of intraepithelial lymphocytes, increased levels of mucosal peroxidase activity, and infiltration of the mucosa by CD4(+) T lymphocytes. Equivalent enteropathy was present at all times in BBdp rats and was not influenced by the nature of the diet or by thymectomy at three weeks at age, procedures which prevent the development of diabetes.
conclusionEnteropathy is a consistent feature in the diabetes prone BB rat but it precedes the onset of insulitis and appears to be due to mechanisms distinct from those which cause diabetes. The beneficial effects of the diabetes retardant hydrolysed casein diet on diabetes are not due to an effect on intestinal architecture per se but mucosal damage may be necessary for the development of autoreactivity in the pancreas.
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