ArticleAnnals of the rheumatic diseases2004
Association of the oestrogen receptor alpha gene polymorphisms with disease onset in systemic lupus erythematosus.
Article in Annals of the rheumatic diseases, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Pooled it
- Construction of competing endogenous RNA networks in systemic lupus erythematosus by integrated analysis.Frontiers in medicine · 2024Article
- Systemic Lupus Erythematosus in Children and Young People.Current rheumatology reports · 2021Review
- Estrogen Receptor Alpha Signaling Is Responsible for the Female Sex Bias in the Loss of Tolerance and Immune Cell Activation Induced by the Lupus Susceptibility LocusFrontiers in immunology · 2020Article
- Clinical implications of systemic lupus erythematosus without and with antiphospholipid syndrome in peri- and postmenopausal age.Przeglad menopauzalny = Menopause review · 2018Review
- Sex Hormones in Acquired Immunity and Autoimmune Disease.Frontiers in immunology · 2018Review
- Estrogen receptor alpha gene (ESR1) polymorphism and its interaction with smoking and drinking contribute to susceptibility of systemic lupus erythematosus.Immunologic research · 2017Article
- The Role of Estrogen Membrane Receptor (G Protein-Coupled Estrogen Receptor 1) in Skin Inflammation Induced by Systemic Lupus Erythematosus Serum IgG.Frontiers in immunology · 2017Article
- Application of Various Statistical Models to Explore Gene-Gene Interactions in Folate, Xenobiotic, Toll-Like Receptor and STAT4 Pathways that Modulate Susceptibility to Systemic Lupus Erythematosus.Molecular diagnosis & therapy · 2016Article
- Estrogen receptor alpha signaling promotes Sle1-induced loss of tolerance and immune cell activation and is responsible for sex bias in B6.Sle1 congenic mice.Clinical immunology (Orlando, Fla.) · 2015Article
- The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases.Frontiers in immunology · 2015Review
- Hormonal parameters and sex hormone receptor gene polymorphisms in men with autoimmune diseases.Rheumatology international · 2013Article
- Association of estrogen receptor α gene PvuII and XbaI polymorphisms with non-small cell lung cancer.Oncology letters · 2012Article
- Estrogen and autoimmune disease.Clinical reviews in allergy & immunology · 2011Review
- Estrogen receptors in immunity and autoimmunity.Clinical reviews in allergy & immunology · 2011Review
- Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus.Lupus · 2010Article
- Estrogen receptor signaling and its relationship to cytokines in systemic lupus erythematosus.Journal of biomedicine & biotechnology · 2010Review
- Connective tissue diseases: Is combined oral contraceptive use linked to SLE incidence?Nature reviews. Rheumatology · 2009Article
- Association of estrogen receptor alpha gene polymorphisms with cytokine genes expression in systemic lupus erythematosus.Croatian medical journal · 2009Article
- Do Genetic Alterations in Sex Steroid Receptors Contribute to Lacrimal Gland Disease in Sjögren's Syndrome?The open endocrinology journal · 2009Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the genetic influence of PvuII and XbaI polymorphisms of oestrogen receptor alpha (ORalpha) in patients with systemic lupus erythematosus (SLE) in Korea.
methodsGenomic DNA from 268 female controls and 137 female SLE patients (41 childhood onset and 96 adult onset) were analysed using PvuII and XbaI restriction fragment length polymorphism. Comparison of the frequencies of alleles and genotypes was made in control and patient groups and in childhood onset and adult onset SLE subgroups.
resultsAlthough the Pp genotype occurred more often in SLE patients than in controls (p(c) = 0.017), ORalpha genotype distributions of adult onset SLE did not differ significantly from controls. The PP, Pp, and xx genotypes occurred less often in childhood onset SLE (p(c) = 0.0045, 0.0498, and 0.0255, respectively) than in controls. Additionally, the PP genotype was less common in childhood onset than in adult onset SLE (p(c) = 0.016). SLE patients with the PP genotypes were older at disease onset than those with the other genotypes (p = 0.001). Patients with the Xx genotype had an earlier onset of SLE than those with the xx genotype (p = 0.025). The frequency of the combined ppXx genotype was greater in childhood onset SLE than in controls (p(c) = 0.0009) or adult onset SLE (p(c) = 0.027). The same trend was supported by subgroup analyses according to age at menarche and logistic multivariate analyses.
conclusionsORalpha polymorphisms are significantly associated with the age at disease onset in Koreans with SLE.
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